2023年3月20日 · Human growth hormone (HGH) is an important hormone produced by your pituitary gland. Also known as growth hormone (GH), it plays a key role in regulating growth in...

1987年2月1日 · We report a novel enzymatic method by which an E. coli produced precursor to human growth hormone (hGH) can be converted to authentic hGH.

1982年6月5日 · The acute effects of synthetic methionyl human growth hormone produced by recombinant DNA technology were compared with those of pituitary human growth hormone in 22 healthy male volunteers. Both caused increases in somatomedin and triglycerides and decreases in blood urea nitrogen and cholesterol.

1972年1月1日 · The aim of most methods for preparation of clinical grade growth hormone is to produce a high yield of active hormone on a fairly large scale, but not necessarily to obtain a homogeneous preparation. Although there have been a number of methods developed for growth hormone extraction, only those which are used for preparing clinical grade HGH ...

1988年2月1日 · To determine whether the short-term administration of growth hormone inhibits pituitary responsiveness to h-GHRH we measured the somatotroph response to h-GHRH-44 (0.3 μg/kg) stimulation in ten normal subjects from the third to the fifth hour of an infusion of met-hGH (2 μg/kg/h) or saline.

2009年1月1日 · Growth hormone is primarily known to promote longitudinal growth in children and adolescents, but has also various important metabolic functions throughout adult life. Effects of hGH on the adult organism are well established from studies with recombinant growth hormone (rhGH) therapy in growth hormone deficient subjects.

In our previous study, a mixed feed strategy using methanol and 50 g/L sorbitol showed a significant increase in the productivity of recombinant hGH (r-hGH) expressed in P. pastoris in which cell biomass reached 108 g/L (dry cell weight (DCW)), total protein was 0.807 g/L and r-hGH concentration was 0.667 g/L following 30 hours induction .

To determine whether the short-term administration of growth hormone inhibits pituitary responsiveness to h-GHRH we measured the somatotroph response to h-GHRH-44 (0.3 micrograms/kg) stimulation in ten normal subjects from the third to the fifth hour of an infusion of met-hGH (2 micrograms/kg/h) or …

2018年3月16日 · In this Review, we describe the history of GH research and clinical use with a particular focus on disorders in childhood. The great complexity of the growth hormone (GH)–insulin-like growth...

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