2024年12月25日 · HGS (Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate) is a Protein Coding gene. Diseases associated with HGS include Tuberculosis and Schwannomatosis, Vestibular. Among its related pathways are Response …

2024年12月10日 · The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene. [5] [6] [7]

Hgs is a novel Smad5 interactor and an inhibitor of bone morphogenetic protein (BMP) signaling. These results indicate that Tsg101 is required for the formation of stable vacuolar domains within the early endosome that develop into multivesicular body (MVBs) and Hrs is required for the accumulation of internal vesicles within MVBs.

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for …

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for …

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. 这个基因编码的蛋白质调节内质网分类，并在膜受体的回收和降解中扮演关键角色。 编码的蛋白质将单泛素化的膜蛋白分类到多泡体中，使这些蛋白质靶向溶酶体依赖的降解。 [由RefSeq, 2010年12月提供]

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). [provided by Alliance of Genome Resources, Apr 2022] — Master of Bioactive Molecules

2017年10月5日 · HGNC Approved Gene Symbol: HGS. Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38) : 17:81,684,011-81,702,121 (from NCBI) Asao et al. (1997) cloned a 110-kD phosphotyrosine protein inducible by stimulation with interleukin-2 (IL2; 147680). They isolated a cDNA clone for the pp110 from the MOLT-beta T-cell line.