Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1][2] They also respond to instances of pseudohypoxia, such as thiamine deficiency. [3][4] Both hypoxia and pseudohypoxia leads to impairment of adenosine triphosphate (ATP) production by the mitochon...

摘 要：缺氧诱导因子-1(hif-1) 和缺氧诱导因子-2(hif-2) 是细胞应对缺氧时关键的转录因子，在生物体 生理及病理过程中有重要的作用。 HIF 由一个α亚基和一个β亚基组成二聚体。

2025年1月18日 · HIF-1 predominantly binds to genes regulating carbohydrate metabolism, while HIF-2 binds to genes that play an essential role in stem cell pluripotency by mediating the Octamer transcription factor 4 (Oct4) pathway. Additional studies show that different cancer cell lines exhibit diverse binding patterns for HIF-1 and HIF-2.

HIF-2是由HIF-2α和HIF-2β相结合发挥作用，但是HIF-2α的相对少一点，它仅表达于血管内壁细胞以及部分的Ⅱ型肺细胞，所以它的作用不像HIF-1α那么重要。 缔造HIF领域研究基石--克隆HIF基因. 1995年Semenza教授成功克隆了HIF-1基因并发表。 这个工作其中也有我们华人科学者的参与——王广泉博士后做了这项工作。...

Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1 alpha, but also more cell-specific HIF-2 alpha, is an important regulator of the hypoxia response.

HIF is an α/β heterodimer that binds hypoxia response elements (HREs) at target gene loci under hypoxic conditions (Figure 1). In the presence of oxygen, HIF is inactivated by posttranslational hydroxylation of specific amino acid residues within its α subunits.

2024年9月5日 · Hypoxia-inducible factor 2α (HIF-2α) is a critical transcription factor that regulates cellular responses under hypoxic conditions. In situations of insufficient oxygen supply or patients with Von Hippel–Lindau (VHL) mutations, HIF-2α accumulates and forms a heterodimeric complex with aryl hydrocarbon receptor nuclear translocator (ARNT, or HIF-β).

2025年1月18日 · In this review, we summarize the similarities and differences between HIF-1α and HIF-2α in their structure, expression, and DNA binding. We also discuss the canonical and non-canonical regulation of HIF-1α and HIF-2α under hypoxic and normal conditions. Finally, we outline recent strategies aimed at targeting HIF-1α and/or HIF-2α.

2023年3月4日 · Tumors driven by deficiency of the VHL gene product, which is involved in degradation of the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted inhibition of this pathway. Belzutifan, a highly specific and well-tolerated HIF2α inhibitor, recently received FDA appro …

2 天之前 · The cells were then exposed to hypoxic conditions (1% O 2, balanced with 5% CO 2 and 95% N 2) using an InVivo2400 hypoxia workstation (Ruskinn Technologies) for 4 h, with or without PT2567 ...