2019年10月31日 · Germline-targeting HIV vaccine design aims to induce bnAbs by first priming bnAb-precursor B cells and then shepherding B cell affinity maturation with a series of …

These strategies now include germline-targeting, lineage-based, and structure-guided immunogen design. This narrative review outlines the historical context of HIV vaccinology and …

Here we review aspects of the medicinal chemistry and history of drug design for HIV and HCV, targeting similar stages in the viral life cycle. At present, 24 drugs have been formally approved...

2024年11月3日 · The discovery of effective strategies for rapid design of immunogens to induce HIV-1 broadly neutralizing antibodies (bnAbs) is critical to vaccine design for HIV-1 and for …

2018年7月7日 · This review examines the principles of designing a vaccine aimed at selectively augmenting immunological correlates of protection, including viral neutralization, with a …

Overcoming envelope metastability is crucial to trimer-based HIV-1 vaccine design. Here, we present a coherent vaccine strategy by minimizing metastability. For 10 strains across five …

Resolving high‐resolution structures of the HIV‐1 Env trimer was instrumental in understanding and improving recombinant HIV‐1 Env trimers that mimic the structure of viral HIV‐1 Env …

2018年7月11日 · Alter and Barouch review two distinct HIV vaccine design approaches: structure-based design of HIV envelope immunogens to induce neutralizing antibodies and driving non …

These strategies now include germline-targeting, lineage-based, and structure-guided immunogen design. This narrative review outlines the historical context of HIV vaccinology and …

Germline-targeting vaccine design offers the potential to initiate the induction of specific classes of protective antibodies against HIV or other pathogens that have eluded vaccine development. …