Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family. Most people with HTLV-1 infection do not appear to develop health conditions that can be directly linked to the infection.

2022年1月14日 · So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes. HIV replication induces the apoptosis of CD4 lymphocytes, leading to the …

Retroviral coinfections with HIV-1 and HTLV-1 or with HIV-1 and HTLV-2 occur with variable frequencies throughout the world with the highest prevalence in large metropolitan areas in the Americas, Europe, and Africa. The recognition that retroviral coinfections exist dates back to the discovery of HIV-1 over 25 years ago.

HIV/HTLV-1 coinfection is associated with accelerated progression to AIDS and worse outcomes of HIV-related opportunistic infections. 5-7 Human T-cell lymphotropic virus type 1 induces HIV viral replication and the transition from M- to T-tropic HIV phenotype, which is often a marker of HIV disease progression. 8 In addition, compared to ...

2018年5月28日 · HTLV-1 and HIV-1 are frequent co-pathogens, however, despite its potential for accelerated progression of HIV disease and the risk of developing adult T-cell lymphoma/leukemia (ATLL), HTLV-1 is seldom considered for investigation in the HIV-1 …

2024年5月25日 · In 2018, we asked WHO to adopt the sexually transmitted oncovirus, human T-cell leukaemia virus 1 (HTLV-1) as a threat to human health. 1 Consequently, WHO announced that HTLV-1's elimination is targeted in their Global Health Sector Strategies on HIV, viral hepatitis, and sexually transmitted infections by 2030. 2 WHO also assigned a new Intern...

HIV 复制诱导 CD4 淋巴细胞凋亡，导致获得性免疫缺陷综合征 (AIDS) 的发展。 经过长时间的临床潜伏期后，HTLV-1 可以转化淋巴细胞，随后出现不受控制的增殖，并出现一种称为成人 T 细胞白血病 (ATLL) 的疾病。 某些受感染的患者会出现称为 HTLV-1 相关性脊髓病的神经性自身免疫性疾病，也称为热带痉挛性截瘫 (HAM/TSP)。 这两种病毒都通过输血、组织/器官移植、母乳喂养和性交在个体之间传播。 在宿主体内，这些病毒可以利用无细胞或细胞间传播模式传播。 在这篇 …

So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes.

Summary: Important clinical effects of HTLV/HIV co-infection include the higher rates of myelopathy and other neurological disorders and the poor predicative value of CD4+ cell counts as a surrogate for immune suppression. Current antiretroviral therapies in isolation have no proven effect on HTLV-1/2 proviral load.

2024年7月25日 · The most well-known human retrovirus is human immunodeficiency virus (HIV). But HTLV-1 acts very differently from HIV. While both HTLV-1 and HIV infect your immune system, HTLV-1 doesn’t destroy your T cells and doesn’t cause symptoms in most people.