The HIV-1 Rev response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs. In the presence of the HIV-1 accessory protein Rev , HIV-1 m RNAs that contain the RRE can be exported from the nucleus to the cytoplasm for downstream events such as ...

The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 ...

2024年5月17日 · During HIV infection, specific RNA-protein interaction between the Rev response element (RRE) and viral Rev protein is required for nuclear export of intron-containing viral mRNA transcripts....

HIV利用一种跨作用的病毒蛋白Rev和一种顺式作用的RNA二级结构——Rev响应元素（RRE），后者存在于所有保留内含子的病毒mRNAs中，来解决这个问题。 Rev蛋白是由完全剪接过的病毒mRNA持续产生的。 翻译成蛋白质后，Rev会被运送进入细胞核，在那里它与RRE结合并形成聚合 …

Cellular restrictions on the export of incompletely spliced transcripts are overcome by a viral protein, Rev, and an RNA structure found in all unspliced and incompletely spliced viral mRNAs, the Rev Response Element (RRE). Primary HIV isolates display substantial variation in the sequence and functional activity of Rev proteins.

人类免疫缺乏病毒 的 Rev响应元件 （英语： Rev response element， RRE）是一个高度结构化的长约350核苷酸的RNA片段，位于病毒基因 Env 的蛋白编码区内部。 在HIV-1的辅助蛋白 Rev 存在的情况下，带有RRE的HIV-1 mRNA 会从 细胞核 输出到 细胞质 中，参与进一步的 翻译 与病毒包装 [1][2]。 HIV-1 RNA的出核过程：在早期（图上部）转录产生的9kb RNA会剪切为 2kb RNA再运输出核。 其中一个2kb RNA会翻译为 Rev 蛋白，再重新输入回核内。 在晚期（图下部） Rev …

2025年1月6日 · The HIV-1 Rev-RRE regulatory axis plays a crucial role in viral replication by facilitating the nucleo-cytoplasmic export and expression of viral mRNAs with retained introns. In this study, we investigated the impact of variation in Rev-RRE functional activity on HIV-1 replication kinetics and reactivation from latency.

2010年6月28日 · In the case of HIV, viral replication requires assembly of an RNP composed of the Rev protein homooligomer and the Rev response element (RRE) RNA to mediate nuclear export of unspliced viral mRNAs. Assembly of the functional Rev-RRE complex proceeds by cooperative oligomerization of Rev on the RRE scaffold and utilizes both protein-protein and ...

2015年6月12日 · HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. After translation, Rev enters the nucleus and binds the Rev response element (RRE), a ~350 nucleotide, highly structured element embedded in the env gene in unspliced and singly spliced viral RNA transcri …

2022年11月1日 · Primary HIV isolates display substantial variation in the sequence and functional activity of Rev proteins. We analyzed Rev from two primary isolates with disparate activity that resulted in...