Vpr, a 96 amino acid 14-kDa protein, plays an important role in regulating nuclear import of the HIV-1 pre-integration complex, and is required for virus replication and enhanced gene expression from provirus in dividing or non-dividing cells such as T cells or macrophages. [3]

2021年6月27日 · 近日，中国医科大学尚红院士团队的梁国新教授课题组在Nature Communications发表题为Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages 的文章，该研究首次鉴定了髓系细胞（巨噬细胞和树突状细胞）特异性表达的新型宿主限制因子溶酶体跨膜蛋白5 ...

2021年11月25日 · Our findings show that Vpr independently targets hHR23A- and DCAF1- dependent pathways and highlight HIV-1 Vpr as a versatile module that interferes with DNA repair and protein degradation...

2021年7月8日 · 近日，中国医科大学 尚红院士团队的 梁国新教授课题组在 Nature Communications发表题为 Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages 的文章， 该研究首次鉴定了髓系细胞（巨噬细胞和树突状细胞）特异性表达的新型宿主限制因子溶酶体跨膜蛋白5 ...

HIV-1 viral protein R (VpR) is a multifunctional protein that plays specific roles at multiple stages of the HIV-1 viral life cycle and affects anti-HIV functions of the immune cells. VpR is required for efficient viral replication in nondividing cells such as macrophages, and it promotes, to some extent, viral replication in the proliferating ...

2021年6月17日 · Here, we report that Vpr counteracts lysosomal-associated transmembrane protein 5 (LAPTM5), a potent inhibitor of HIV-1 particle infectivity, to enhance HIV-1 infection in macrophages. LAPTM5...

2024年6月29日 · HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env).

Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of cellular and viral proteins. The functions of many of these interactions in the pathogenesis of HIV-1 have been identified. …

2023年9月6日 · We found that HIV-1 infection induces ciTRAN expression in a Vpr-dependent manner and that ciTRAN interacts with SRSF1, a protein known to repress HIV-1 transcription. Our results suggest that HIV-1 hijacks ciTRAN to exclude serine/arginine-rich splicing factor 1 (SRSF1) from the viral transcriptional complex, thereby promoting efficient viral ...

The HIV protein, Vpr, is a multifunctional accessory protein critical for efficient viral infection of target CD4 + T cells and macrophages. Vpr is incorporated into virions and functions to transport the preintegration complex into the nucleus where the process of viral integration into the host genome is completed.