Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. [1]

Jul 27, 2021 · Vpu is an HIV-1 accessory protein generated from Env / Vpu encoded bicistronic mRNA and localized in cytosolic and membrane regions of cells capable of being infected by HIV-1 and that regulate HIV-1 infection and transmission by downregulating BST-2, CD4 proteins levels, and immune evasion.

Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins.

近日，一篇发表在国际杂志 Cell Reports上题为“HIV-1 Vpu restricts Fc-mediated effector functions in vivo”的研究报告中，来自蒙特利尔大学等机构的科学家们通过研究发现，用来研究非中和性抗体抵御HIV功效的…

Sep 6, 2023 · We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a single-pass membrane protein....

Jun 4, 2016 · Vpu 蛋白通过多种机制促进 HIV-1 病毒的释放，包括在细胞膜上形成选择性阳离子通道来增强通透性；诱导细胞表面病毒受体 CD4 分子的降解；拮抗宿主抗病毒因子骨髓基质细胞抗原 2（Bone marrow stromal cell antigen 2，BST-2）的功能等。

Feb 28, 2017 · Viral protein U (Vpu) is a unique protein encoded by human immunodeficiency virus type 1 (HIV-1) and related lentiviruses, playing multiple roles in viral replication and pathogenesis. In this review, we briefly summarize the most up-to-date knowledge of HIV-1 Vpu.

Jul 1, 2008 · Vpu is an accessory viral protein almost unique to HIV-1 among primate immunodeficiency viruses, and has two major functions: degradation of the CD4 molecule in endoplasmic reticulum and enhancement of virion release from cells.

Vpu is a small membrane protein encoded by HIV-1 and some SIV isolates. The protein is best known for its ability to degrade CD4 and to enhance the release of progeny virions from infected cells. However, Vpu also promotes host-cell apoptosis by deregulating the NFκB signaling pathway and it assembles into cation-conducting membrane pores.

Sep 1, 2003 · This review focuses on presenting our current knowledge of the HIV-1-specific Vpu protein and its essential role in regulating viral particle release, viral load and expression of the CD4 receptor.