2021年11月25日 · Our findings show that Vpr independently targets hHR23A- and DCAF1- dependent pathways and highlight HIV-1 Vpr as a versatile module that interferes with DNA …

2021年6月27日 · 近日，中国医科大学尚红院士团队的梁国新教授课题组在Nature Communications发表题为Vpr counteracts the restriction of LAPTM5 to promote HIV-1 …

2024年6月29日 · HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env).

Deletion of the vpr gene reduces the virulence of HIV-1 dramatically, indicating the importance of this protein for the virus. This review describes the current findings on several established …

Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators. J …

2023年9月6日 · We found that HIV-1 infection induces ciTRAN expression in a Vpr-dependent manner and that ciTRAN interacts with SRSF1, a protein known to repress HIV-1 transcription. …

2024年12月12日 · 在HIV-1感染的细胞内，辅助病毒蛋白r（viral protein r，Vpr）调控多种生物过程，包括细胞周期进展、DNA修复和凋亡。 DNA甲基化在不改变DNA序列下调控基因表达， …

2021年6月17日 · Here, we report that Vpr counteracts lysosomal-associated transmembrane protein 5 (LAPTM5), a potent inhibitor of HIV-1 particle infectivity, to enhance HIV-1 infection …

HIV-1 Vpr and exogenously expressed Tat induce apoptosis of host cells. The apoptosis induction efficiency of Tat exon 1 and Vpr variants was measured by flow cytometry. They were …

2014年3月31日 · Although different HIV-1-induced pathways for apoptosis induction have been described, Vpr appears as one of the main actors of the cell death observed during HIV-1 …