2021年11月25日 · Our findings show that Vpr independently targets hHR23A- and DCAF1- dependent pathways and highlight HIV-1 Vpr as a versatile module that interferes with DNA repair and protein degradation...

2021年6月27日 · 近日，中国医科大学尚红院士团队的梁国新教授课题组在Nature Communications发表题为Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages 的文章，该研究首次鉴定了髓系细胞（巨噬细胞和树突状细胞）特异性表达的新型宿主限制因子溶酶体跨膜蛋白5 ...

2024年6月29日 · HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env).

Deletion of the vpr gene reduces the virulence of HIV-1 dramatically, indicating the importance of this protein for the virus. This review describes the current findings on several established functions of HIV-1 Vpr and some possible roles proposed for this protein. Because Vpr exploits cellular proteins and pathways to influence the biology of ...

Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators. J Virol. 2002;76:9724–9734. doi: 10.1128/JVI.76.19.9724-9734.2002.

2023年9月6日 · We found that HIV-1 infection induces ciTRAN expression in a Vpr-dependent manner and that ciTRAN interacts with SRSF1, a protein known to repress HIV-1 transcription. Our results suggest that HIV-1 hijacks ciTRAN to exclude serine/arginine-rich splicing factor 1 (SRSF1) from the viral transcriptional complex, thereby promoting efficient viral ...

2024年12月12日 · 在HIV-1感染的细胞内，辅助病毒蛋白r（viral protein r，Vpr）调控多种生物过程，包括细胞周期进展、DNA修复和凋亡。 DNA甲基化在不改变DNA序列下调控基因表达，在生理过程中扮演着至关重要的角色。 然而，关于Vpr对人类CD4+ T细胞DNA甲基化作用研究尚未得到充分探索。 近日，中山大学附属第三医院王培培为第一作者，中山大学中山医学院蔡金锋博士和中山大学附属第三医院高志良教授为共同通讯作者在《Virology Journal》杂志发表题为“ Vpr …

2021年6月17日 · Here, we report that Vpr counteracts lysosomal-associated transmembrane protein 5 (LAPTM5), a potent inhibitor of HIV-1 particle infectivity, to enhance HIV-1 infection in macrophages. LAPTM5...

HIV-1 Vpr and exogenously expressed Tat induce apoptosis of host cells. The apoptosis induction efficiency of Tat exon 1 and Vpr variants was measured by flow cytometry. They were transfected in Hela cells with wild type proteins as controls and after 24 hrs; cells were fixed and stained with PI. Cells were then analyzed by flow cytometer.

2014年3月31日 · Although different HIV-1-induced pathways for apoptosis induction have been described, Vpr appears as one of the main actors of the cell death observed during HIV-1 infection. However, it is still controversial how Vpr induces apoptosis and/or necrosis.