Cell Metabolism（IF:29）如何用“糖酵解+乳酸化”两大国自然热点 …
这部分结果表明HSC特异性Hk2缺失可减轻造血干细胞中的H3K18la，并抑制肝纤维化，而体内慢性和全身乳酸治疗可恢复胶原沉积和a-SMA表达。 以往研究报道显示成年小鼠的系统性Hk2缺 …
Metabolism：陈莉明/孙海鹏团队揭示支链氨基酸的异常增多会促 …
2024年12月5日 · 在慢性肾脏疾病（CKD）的背景下，多项研究证实低蛋白饮食（LPD）能有效缓解DKD患者症状，且低蛋白摄入与DKD患者的肾小球滤过率（GFR）和蛋白尿下降密切相关 …
Hexokinase 2-mediated gene expression via histone lactylation is ...
2023年8月8日 · In this study, we obtained evidence that HK2-induced lactate influences gene expression via histone lactylation and not histone acetylation. We next found that the induction …
Hexokinase 2-driven glycolysis in pericytes activates their ...
2021年10月14日 · Mechanistically, combined proteomics and metabolic flux analysis reveals elevated hexokinase 2 (HK2)-driven glycolysis in tumor pericytes, which up-regulates their …
Cell Metabolism ：尊嘟假嘟，组蛋白乳酸化促进肝纤维化？ - 知乎
近期发表在Cell Metabolism杂志上的一篇题为“Hexokinase2-mediated gene expression via histonel actylation is required for hepatic stellate cell activation and liver fibrosis”的文章中，研 …
Hexokinase 2-mediated gene expression via histone lactylation is ...
Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by histone lactylation …
A) Expression of α-SMA expression in HK-2 cells treated
Collectively, we identified that hsa-miR-494-3p, a miRNA induced in both circulation of AKI patients and hypoxia-reoxygenation-treated HK2 cells, enhanced renal inflammation by …
Expression of E-cadherin, CK, a-SMA, vimentin in HK-2 cells by ...
(A-C)The HK-2 cells under 30 mM glucose (B) or 30 mM glucose+cont siRNA (C) showed a loss of CK and E-cadherin and an increase of a-SMA and vimentin expression compared to that of …
TGF-b1 induces the expression of a-SMA in HK-2 cells. (a and b ...
We investigated the effect of PTX3 on cultured human proximal tubular epithelial (HK-2) cells and a rat unilateral ureteral obstruction (UUO) model of renal fibrosis. Method... ...
Hexokinase 2 couples glycolysis with the profibrotic actions
Yin et al. found that the glycolytic enzyme hexokinase 2 (HK2) was highly abundant in lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and that TGF-β induced the …