2025年3月30日 · HK3 (Hexokinase 3) is a Protein Coding gene. Diseases associated with HK3 include Long Qt Syndrome. Among its related pathways are glycolysis (BioCyc) and GDP-glucose biosynthesis II. Gene Ontology (GO) annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor.

Hexokinase III, also known as hexokinase C, is an enzyme which in humans is encoded by the Hk3 gene on chromosome 5. [5][6] Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways.

2024年12月31日 · HK3 emerges as a novel prognostic biomarker for HCC, exerting regulatory influence over cellular proliferation, metastasis, and invasiveness. These findings indicate that HK3 holds promise as a potential candidate for treatment and prognosis of HCC.

2022年5月11日 · We found that HK3 knockout (HK3-null) AML cells showed an accumulation of reactive oxygen species (ROS) as well as DNA damage during ATRA-induced differentiation.

HK3 may stimulate the abundance of infiltrating monocytes/macrophages presenting surface markers and regulate the key molecular subgroups of immune checkpoint molecules of exhaustive T cells, thus inducing the microenvironmental characteristics of active anti-tumor immune responses.

Regarding glucose metabolism, the initial step is to generate glucose-6-phosphate by phosphorylating glucose with hexokinases-3 (HK3). According to a recent study, HK3 has a functional role in the treatment of acute promyelocytic leukemia and colorectal cancer.

2024年8月23日 · HK3 promotes tumor immune evasion by upregulating PD-L1 expression. To elucidate the potential relationship between HK3 and PD-L1, we selected the cell lines as our primary subjects of research.