HLA-B5 (B5) is an HLA - B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes. [1]

To quantify by meta-analysis the genetic effect of the HLA–B5 or HLA–B51 (HLA–B51/B5) allele on the risk of developing Behçet’s disease (BD) and to look for potential effect modifiers. Relevant studies were identified using the PubMed Medline database and manual searches of …

Recent findings HLA-B∗51 remains the most important genetic factor in Behçet's syndrome, despite the recent identification of several susceptibility genes. The prevalence of HLA-B∗51 has been shown to differ among phenotype-based clinical clusters in the same patient population.

2020年6月2日 · Both HLA-B5 and HLA-B51 are gene markers that are sometimes present in patients with Behçet’s disease. But there are some people who have this gene marker who don’t have Behçet’s disease.

HLA B*51 is the predominant risk factor for BD in all populations studied, however not all BD patients carry the B*51 allele. The disease is prevalent in countries in the eastern Mediterranean, the Middle East, and East Asia and in individuals of Middle Eastern, Far Eastern and Mediterranean decent.

What is HLA - B5 Test? HLA (human leukocyte antigen) B5 has two splits B•51 and B•52 of which only B•51 is important in the etiology of Behcet's disease (Behçet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body.). It is most prevalent in the Middle East and the Far East.

We conducted a systematic review of the literature to identify studies exploring the association between HLA-B*51 and BD and further highlighted the roles of innate and adaptive immunity in BD.

2009年10月15日 · Objective: To quantify by meta-analysis the genetic effect of the HLA-B5 or HLA-B51 (HLA-B51/B5) allele on the risk of developing Behçet's disease (BD) and to look for potential effect modifiers.

2024年5月3日 · HLA-B*51 is strongly associated with BD with approximately 60% of patients being positive, as opposed to about 15% positivity in healthy individuals across different ethnicities. Due to low specificity, HLA-B*51 positivity is not diagnostic for BD.

The association of HLA-B51 and Behcet's disease has been reported in patients of many ethnic groups. Approximately 20% of healthy individuals of various ethnic origins are HLA-B51 positive, compared to 50 to 80% of patients with Behcet's disease.