HLA region of Chromosome 6 The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]

HLA-A is one of three major types of human MHC class I transmembrane proteins. The others are HLA-B and HLA-C. [2] The protein is a heterodimer, and is composed of a heavy α chain and smaller β chain. The α chain is encoded by a variant HLA-A gene, and the β chain (β 2 -microglobulin) is an invariant β 2 microglobulin molecule. [3]

HLA-DR antigen specificities (i.e., DR1 to DR18) are determined by the polymorphic DRβ1 chains encoded by DRB1 alleles. HLA haplotypes of certain DRB1 alleles contain specifically linked DRB3, DRB4, or DRB5 locus. The DP and DQ families each have one expressed gene for α and β chains and additional unexpressed pseudogenes.

2013年7月18日 · The Major Histocompatibility complex (MHC) system known as the human leukocyte antigen (HLA) in humans is located on the short arm of chromosome 6 (6p21.3) and contains the most polymorphic gene cluster of the entire human genome.

The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. It encodes cell surface molecules specialized to present antigenic peptides to the T-cell receptor (TCR) on T cells. (See also Overview of the Immune System.)

2024年12月25日 · HLA-A (Major Histocompatibility Complex, Class I, A) is a Protein Coding gene. Diseases associated with HLA-A include Severe Cutaneous Adverse Reaction and Hla Modifier. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include RNA binding and peptide antigen binding.

Here, we review each of the 6 HLA binding pockets of HLA class I (HLA-I) molecules. The binding specificity of pockets B and F are strong determinants of peptide binding and have been used to classify HLA into supertypes, a useful tool to predict peptide binding to a given HLA.

HLA class I molecules consist of two heterodimer polypeptide chains, a heavy α chain, and a lighter β 2-microglobulin chain. The α chain has three extracellular domains (α 1, α 2, and α 3), a transmembrane region, and a C-terminal cytoplasmic tail.

2025年3月16日 · HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).

Human Leucocytes Antigen (HLA) is used for MHC gene products involved in antigen recognition by the T-lymphocytes. MHC genes are present on the short arm of chromosome NO: 6. In human MHC is referred to as human leukocyte antigen (HLA).