HLA haplotypes of certain DRB1 alleles contain specifically linked DRB3, DRB4, or DRB5 locus. The DP and DQ families each have one expressed gene for α and β chains and additional unexpressed pseudogenes. The DQA1 and DQB1 gene products associate to form DQ molecules, and the DPA1 and DPB1 products form DP molecules.

2015年2月17日 · We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data. Does any of this interest you? Would you like to publish your population frequency data on HLA and KIR? (In collaboration with Human immunology) See more information in Hum Immunol, 76, 393-394.

2023年8月14日 · The HLA haplotype is a combination of linked HLA genes (HLA-A, -B,-C,-DR, -DQ,-DP) transmitted on a single parental chromosome. HLA antigens are expressed on the surface of many cells and play a major role in self-recognition, evoking the immune response to an antigenic stimulus, and to the orchestration of cellular and humoral immunity. [1]

2023年4月24日 · Graves disease is associated with HLA-DR3. In addition to environmental factors, the HLA haplotype plays a significant role in disease development. Important clinically, HLA typing may help to predict the outcome of Graves disease before and post-antithyroid medical therapy.

2009年1月9日 · The HLA-DRB loci are variable in number and MHC haplotype-dependent. The HLA-DRB locus in the PGF haplotype contains four copies of the HLA-DRB gene, HLA-DRB1 (coding), -DRB5 (coding),...

HLA Haplotype Validator (HLAHapV) is a program originally developed to impute chromosomal phase from genotype data using reference haplotype data. We updated and adapted HLAHapV to systematically compare observed and estimated haplotypes. We also used HLAHapV to identify haplotypes when uninformative HLA genotypes are present in families.

2023年3月22日 · In this study, a worldwide comparison of HLA class I and class II diversity was carried out. Multidimensional scaling techniques were applied to 50 HLA-A and HLA-B (class I) as well as 13 HLA-DRB1 (class II) first-field frequencies in 200 populations from all continents.

HLA typing became the most critical component of matching hematopoietic cells between donors and recipients to help avoid acute graft rejection and graft-versus-host disease (GVHD) and improve patient outcomes. 1. Modern HLA typing techniques deliver much more detailed information than earlier methods, identifying finer levels of mismatch.

2023年7月26日 · We provide detailed guidance on performing standard quality control measures for input genotyping data and describe options to impute HLA alleles and amino acids either locally or using the...

2018年1月2日 · Dendrou and colleagues review mechanisms of HLA–peptide–T cell receptor binding in health and disease and discuss how this knowledge may be translated into clinical benefit.