
Human leukocyte antigen - Wikipedia
The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1]
The HLA genomic loci map: expression, interaction, diversity and ...
2009年1月9日 · The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal position 6p21 that encodes the six classical transplantation HLA genes and at least 132...
The most frequent HLA alleles around the world: A ... - ScienceDirect
2024年6月1日 · First, they show that very frequent HLA alleles exist everywhere, even at the most polymorphic HLA-B and DRB1 loci. Many of them are either universal or present in multiple geographic regions, suggesting that the HLA allelic pool is widely shared among populations on a global scale, as are the majority of genome-wide SNPs [85].
The HLA System: Genetics, Immunology, Clinical Testing, and …
The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed ...
Major histocompatibility complex: Antigen processing and …
2013年7月18日 · The Major Histocompatibility complex (MHC) system known as the human leukocyte antigen (HLA) in humans is located on the short arm of chromosome 6 (6p21.3) and contains the most polymorphic gene cluster of the entire human genome.
Human Leukocyte Antigen (HLA) System: Genetics and …
The human leukocyte antigen (HLA) system is one of the most crucial host factors influencing disease progression in bacterial and viral infections. This review provides the basic concepts of the structure and function of HLA molecules in humans. ...
A genomic perspective on HLA evolution - PMC
We discuss how findings from genomewide association studies impact the evolutionary study of HLA genes, and how genomic data can be used to survey adaptive change involving interaction at multiple loci. We discuss the methodological developments which are necessary to correctly interpret genomic analyses involving the HLA region.
The characteristic of HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA
2024年8月6日 · Our analysis of the alleles and haplotypes revealed a high degree of polymorphism within these loci. A total of 289 unique HLA alleles were identified, with the HLA-B locus exhibiting the most significant diversity, while HLA-DRB4 displayed the lowest variation.
Human Leukocyte Antigen (HLA) System - The Merck Manuals
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. T cells that express CD8 molecules react with class I MHC molecules.
Histocompatibility - The EBMT Handbook - NCBI Bookshelf
2024年4月11日 · The key loci to include in the typing and matching process for UDs are minimally HLA-A, HLA-B, HLA-C, and HLA-DRB1 at a high resolution and optionally HLA-DQB1 and HLA-DPB1.
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