2009年1月9日 · Gene map of the human leukocyte antigen (HLA) region. The major histocompatibility complex (MHC) gene map corresponds to the genomic coordinates of 29 677 984 (GABBR1) to 33 485 635 (KIFC1)...

HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]

2023年3月22日 · Unsupervised double clustering-based heat map of 13 HLA-DRB1 allele groups in 197 worldwide populations. Frequencies of individual allele groups are plotted according to the allele group (top and bottom) and population (left and right) minimum variance squared Euclidean distance dedrograms.

HLA frequencies show widespread variation across human populations. Demographic factors as well as selection are thought to have shaped HLA variation across continents. In this study, a worldwide comparison of HLA class I and class II diversity was ...

2023年3月23日 · This analysis of HLA frequencies in a unique set of worldwide populations confirms previous findings on the remarkable similarity of class I frequencies to geography, but also shows a more complex development for class II, with implications for both human evolutionary studies and biomedical research.

Hla-mapper provides a reliable map of HLA sequences, allowing accurate downstream analysis such as variant calling, haplotype inference, and allele typing. Moreover, hla-mapper supports whole genome, exome, and targeted sequencing data.

HLA-net is an European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics.

Additionally, we now publish monthly HLA Nomenclature Updates, both in journals and online, to provide quick and easy access to new sequence information. Access sequence alignments and files by clicking on the map of the HLA region below. To see sequences and reference information, use the map below to click on the gene whose data interests you.

The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal position 6p21 that encodes the six classical transplantation HLA genes and at least 132 protein coding genes that have important roles in the regulation of the immune system as well as some other fundamental molecul …

Generate Charts & Maps. Provides allele and haplotype frequency charts and maps. Enter an allele or haplotype, and select the geographic region(s) of interest. This programme requires that the names submitted correspond to valid allele or haplotype names (currently allele names at …