HLA-G的表达保护靶细胞免受外周血和NK细胞系中NK细胞毒性的影响。ILT2与HLA-G相互作用也抑制了靶细胞诱导的NK细胞产生极化IFN-γ。可溶性HLA-G（sHLA-G）对NK细胞（CD56bright和CD56dim）的趋化性、细胞因子和趋化因子的分泌有不同程度的调节作用。

HLA class I molecules are critical regulators of NK cell activation through the interaction with inhibitory- as well as activating NK cell receptors, hence, HLA molecules act as critical immune checkpoints for NK cells.

HLA-DR + NK cells are functionally active: they produce proinflammatory cytokines, degranulate, and easily proliferate in response to stimuli. Additionally, HLA-DR + NK cells seem able to take in and then present certain antigens to CD4 + and CD8 + T cells, inducing their activation and proliferation, which puts them closer to professional ...

NK细胞作为造血干细胞移植后最先重建的固有免疫细胞，有开发成为通用型细胞产品的潜力。 本文从基础HLA和KIR生物学知识开始，回顾分析国外多年积累的临床数据，以期对这一话题进行一个详细的总结。 目录. 一、HLA的生物学原理. 二、KIR的生物学原理. 三、利用HLA与KIR的匹配性优化HSCT移植的临床依据. 四、同种异体NK细胞免疫治疗的匹配原则及应用实例. 一、HLA的生物学原理. 1. HLA基因概况和结构.

2021年7月6日 · Natural killer (NK) cells are innate lymphocytes that can kill diseased- or virally-infected cells, mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines upon activation. NK cells also contribute to the allo-immune response upon kidney transplantation either by promo …

2021年1月29日 · Our study demonstrates the feasibility of genome editing in primary allogeneic NK cells to diminish their recognition and killing by mismatched T cells and is an important prerequisite for using non-HLA-matched primary human NK cells as readily available, "off-the-shelf" immune effectors for a variety of immunotherapy indications in human cancer.

2020年2月17日 · The cytolytic function of NK cells is tightly controlled by activating and inhibitory receptors expressed on the cell surface. Ligands that interact with a variety of NK-cell receptors include the human leukocyte antigen (HLA) molecules, and the regulation of NK-cell function by HLA class I molecules is well-established.

2019年2月18日 · Human NK cells express two different classes of HLA-class I-specific inhibitory receptors: members of the KIR/CD158 family and the CD94/NKG2A (CD94/CD159a) heterodimer. 5,45 KIRs are type I ...

4 天之前 · HLA-E blocks NK and CD8 + T cell attacks 31, whereas HLA-G blocks attacks from CD8 + T, CD4 + T, B (ref. 32) and NK cells and macrophages, prompting research into selective deletion methods.

2020年10月13日 · Using primary NK cells from healthy donors, we demonstrate that HLA-A*23, HLA-A*24, and HLA-A*32 proteins are expressed at different densities and exhibit different capacities to educate and inhibit KIR3DL1-expressing NK cells in vitro. Among the HLA-A Bw4 + allotypes, HLA-A*24 and HLA-A*32 demonstrate the strongest inhibitory capacity.