免疫细胞治疗——TCR-T - 知乎 - 知乎专栏
通过筛选和鉴定能够特异性结合靶点抗原的TCR 序列， 采用基因工程手段将其转入到患者外周血来源的 T 细胞中 ( 或异源 T 细胞) ， 再将改造后的 T 细胞回输至患者体内， 使其特异性识别 …
ASCO 追踪| HLA基因型，为什么是TCR-T细胞治疗领域的关注焦点？
2022年6月7日 · t细胞表面的t细胞受体（tcr）可以特异性识别和结合癌细胞表面的hla-抗原肽复合物，结合后t细胞被活化并释放效应分子攻击癌细胞。 T细胞主要通过两种途径发挥对肿瘤细胞 …
Antigen identification for HLA class I– and HLA class II ... - AAAS
2021年1月8日 · Variation in human leukocyte antigen (HLA) and T cell receptor (TCR) genes is associated with risk of infection and autoimmunity (1, 2) and can influence patient survival to …
TCR-T细胞治疗癌症：当前策略、挑战和前景 - 健康界
2023年2月17日 · 与嵌合抗原受体（CAR）不同，TCR识别来自所有细胞区室蛋白质的HLA呈递肽。 将TCR-T细胞用于过继细胞疗法（ACT）已受到越来越多的关注，特别是随着ACTs治疗实 …
A unified cross-attention model for predicting antigen binding ...
2025年1月28日 · Our method demonstrates superior performance in predicting both peptide-HLA and peptide-TCR binding on multiple independent and external test sets. Notably, on a large …
T cell receptor therapeutics: immunological targeting of the ...
2023年10月27日 · Herein, we review the current cancer treatment landscape using TCRs and TCR-like molecules. This includes adoptive cell transfer of T cells expressing endogenous or …
Antigen identification for HLA class I- and II-restricted T cell ...
A major limitation to understanding the associations of human leukocyte antigen (HLA) and CD8+ and CD4+ T cell receptor (TCR) genes with disease pathophysiology is the technological …
T cell receptor interactions with human leukocyte antigen govern ...
2020年8月14日 · T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for …
Divergent T-cell receptor recognition modes of a HLA-I ... - Nature
2018年3月12日 · Human leukocyte antigen (HLA)-I molecules generally bind short peptides (8–10 amino acids), although extended HLA-I restricted peptides (>10 amino acids) can be …
Determining T-cell Receptor Binding Orientation and Peptide-HLA ...
2 天之前 · The crossing angle of the TCR-C-pHLA binding orientation was measured at 62.9°, which is within the typical canonical binding range of 30-80°. βCDR2, βCDR3 and all three …