HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. [1] B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. [2] …

The presence of the gene HLA–B51 is a risk factor for this disease. However, it must be emphasized that presence of the gene in and of itself is not enough to cause Behcet’s: many …

HLA-B∗51 remains the most important genetic factor in Behçet's syndrome, despite the recent identification of several susceptibility genes. The prevalence of HLA-B∗51 has been shown to …

To quantify by meta-analysis the genetic effect of the HLA–B5 or HLA–B51 (HLA–B51/B5) allele on the risk of developing Behçet’s disease (BD) and to look for potential effect modifiers. …

Behcet’s disease is a systemic inflammatory vasculitis, characterised by oral ulcers, genital ulcers, skin lesions and ocular lesions. It can affect the blood vessels of almost any system involving …

A variation of the HLA-B gene called HLA-B51 increases the risk of developing Behçet disease by about a factor of six, although the mechanism is not well understood. One-third to two-thirds of …

Studies reveal that HLA-B*51 is the primary genetic risk factor, but non-HLA genes (ERAP1, IL-10, IL23R/IL-12RB2), as well as innate immunity genes (FUT2, MICA, TLRs), also contribute. …

2024年5月3日 · HLA-B*51 is strongly associated with BD with approximately 60% of patients being positive, as opposed to about 15% positivity in healthy individuals across different …

2009年10月15日 · The strength of the association between BD and HLA-B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being …

HLA-B51 refers to a molecule that is characterized by the presence of two specific amino acids (Asparagine at position 63 and Phenylalanine at position 67) in the B-pocket of the HLA …