HLA-DM (human leukocyte antigen DM) is an intracellular protein involved in the mechanism of antigen presentation on antigen presenting cells (APCs) of the immune system. [2] It does this by assisting in peptide loading of major histocompatibility complex (MHC) class II membrane-bound proteins. [3] HLA-DM is encoded by the genes HLA-DMA and HLA ...

HLA研究中，模拟免疫反应激活的过程，就要经过 蛋白酶体对抗原（蛋白）的剪切预测 、肽段转运、 肽段和MHC-I结合亲和力预测 以及 T细胞识别预测 等几个重要步骤。 一般可以采用滑动窗口（sliding windows）的方法把可能的肽段都提取出来，MHC结合亲和力预测由软件实现（但效果各有说法，最好多重比较筛选， 软件对比），更严谨的可以用抗原实验来验证（制造目标肽段，做实验查看与MHC的结合情况）。 HLA配型也叫移植配型，HLA基因座位点具有高度多态性，完 …

Peptide loading of class II MHC molecules in endosomal compartments is regulated by HLA-DM. HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound epitopes presented at the cell surface for interaction with T cells. Here, we summarize and discuss recent progress in investigating the molecular mechanisms of action of ...

HLA-DM, a variant of the HLA Class II molecules, is a type of molecule encoded on chromosome 6 that plays a crucial role in presenting peptides from outside the cell and interacting with CD4+ T helper cells on immune cells such as B cells and antigen-presenting cells.

HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound epitopes presented at the cell surface for interaction with T cells. Here, we summarize and discuss recent progress in investigating the molecular mechanisms of action of HLA-DM and HLA-DO and in understanding their roles in immune responses.

Antigen presentation by major histocompatibility complex class II molecules (MHC II) to CD4+ T cells plays a key role in the regulation of the adaptive immune response. Loading of antigenic peptides onto MHC II is catalyzed by HLA-DM (DM), a ...

2012年3月2日 · HLA-DM plays an essential role in the peptide loading of classical class II molecules and is present both at the cell surface and in late endosomal peptide-loading compartments. Trafficking of DM within antigen-presenting cells is complex and is, in part, controlled by a tyrosine-based targeting signal present in the cytoplasmic tail of DMβ.

2015年7月15日 · Removal of CLIP from MHC II and loading of antigenic peptides to MHC II are catalyzed by DM (HLA-DM in humans and H2-M in mice) (7–10). Peptide-loaded MHC II molecules are transported to the cell surface for presentation to CD4 + T cells and stimulation of an immune response.

1999年4月1日 · HLA-DM is the first example of a molecular chaperone that operates in lysosomes: it plays a crucial role in endosomal and lysosomal compartments during loading of major histocompatibility complex (MHC) class II molecules, specialized peptide receptors that are expressed by antigen-presenting cells of the immune system.

HLA-DM has three main functions: it causes the dissociation of CLIP from the peptide binding groove of MHC II, stabalizes and prevents degradation of the empty MHC II, and facilitates the binding of antigen fragments to the open, stabalized binding groove (Janeway et al., 2005).