HLA class II histocompatibility antigen, DP (W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a …

2024年12月25日 · HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) is a Protein Coding gene. Diseases associated with HLA-DPB1 include Berylliosis and Hla Modifier. Among its related pathways are Phosphorylation of CD3 and TCR zeta chains and Immune response NFAT in immune response.

The HLA-DPB1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DPB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and ...

2023年8月24日 · We developed a tool to facilitate the selection of HLA-DPB1 -mismatched unrelated transplantation donors. HLA-DPB1 sequence features in exons 2 and 3 provide optimal information regarding risky mismatches. HLA-DP is a classic transplantation antigen that mediates alloreactivity through T-cell epitope (TCE) diversity and expression levels.

HLA-DPB1 genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia. specifically support the role of classical HLA-DRB1 and DPB1 genes and alleles in susceptibility to primary biliary cirrhosis; HLA-DPB1*0402 might be an independent risk factor for all-cause mortality in ANCA-associated vasculitis.

HLA-DPB 属于 HLA II 类β链旁系同源物。 这种 II 类分子是一种异二聚体，由一条 alpha (DPA) 和一条 beta 链 (DPB) 组成，两者都锚定在膜中。 它通过呈递源自细胞外蛋白的肽在免疫系统中发挥核心作用。 II 类分子在抗原呈递细胞 (APC：B 淋巴细胞、树突细胞、巨噬细胞) 中表达。 β链约为 26-28 kDa，其基因包含 6 个外显子。 外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域，外显子 5 编码细胞质尾部。 在 DP 分子中，α 链和 β 链均包含 …

2021年9月14日 · HLA-DPB1 was upregulated in B cells, CD8 + T cells, monocytes, and NK cells. Overall, the HLA class II genes are differentially expressed in B cells of myasthenia gravis, suggesting their...

In this study, our initial investigation focused on examining the correlation between the rs9277534G/A SNP and DPB1 mRNA expression. The result showed that there was a significant increase in DPB1 mRNA expression in B lymphoblastoid cell lines (BLCLs) with the rs9277534GG genotype compared to rs9277534AA genotype.

2024年12月10日 · Clinical resource with information about HLA-DPB1, A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.,

HLA-DPB属于HLA II类β链平行系。 这个II类分子是一个由α (DPA)和β链 (DPB)组成的核心异二聚体，两者都固定在膜上。 它通过呈现来自细胞外蛋白的肽段在免疫系统中发挥核心作用。 II类分子在抗原呈递细胞（APC：B淋巴细胞，树突状细胞，巨噬细胞）中表达。 β链约26-28 kDa，其基因包含6个外显子。 外显子1编码前导肽，外显子2和3编码两个细胞外结构域，外显子4编码跨膜结构域，外显子5编码胞质尾。 在DP分子中，α链和β链都含有指定肽结合特异性的多态性，从而 …