2024年12月25日 · HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) is a Protein Coding gene. Diseases associated with HLA-DRA include Celiac Disease and Graham Little-Piccardi-Lassueur Syndrome. Among its related pathways are TCR Signaling (Qiagen) and Phosphorylation of CD3 and TCR zeta chains.

HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. However it can pair with, in any individual, the beta chain from 3 different DR beta loci, …

HLA -II型 （HLA-DP, HLA-DM, HLA-DO, HLA-DQ, HLA-DR）编码第二型MHC，将细胞外抗原呈递给CD 4+ T（T-helper cells 辅助T细胞），T细胞增殖，进而刺激B细胞产生抗原特异性抗体（体液免疫）。

HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.

hla-dra 是 hla ii 类α链旁系同源物之一。 这种 II 类分子是由 α 和 β 链组成的异二聚体，它们都锚定在膜中。 该分子在 B 淋巴细胞、树突状细胞和单核细胞/巨噬细胞等各种抗原呈递细胞的表面表达，并通过呈递细胞外蛋白肽，特别是病原体衍生肽，在免疫系统和 ...

2024年11月5日 · HLA-DRA (人类白细胞抗原-DR Alpha)是 人类白细胞抗原系统 （HLA系统）中 MHC II类分子 的重要组成部分，广泛表达于 抗原呈递细胞 (如树突状细胞、单核细胞和B细胞)中。 HLA-DRA在免疫系统中起着关键作用，主要负责将 外源性抗原 呈递给 CD4+ T细胞，从而激活适应性免疫反应。 研究表明，HLA-DRA的表达异常与类风湿性关节炎 (RA，Rheumatoid Arthritis)、系统性红斑狼疮 (SLE，Systemic Lupus Erythematosus)和1型糖尿病 (T1D，Type 1 …

HLA-DR基因表达两个分子量分别为36kD和27kD的HLA蛋白亚基（HLA-DRA和HLA-DRB），对应为alpha链和beta链，属于MHC-II类分子。 Beta链的HLA-DRB基因包含了所有特异性多肽结合区域的多态性，决定了多肽跟MHC-II分子的亲和力。

2024年10月28日 · HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane.

2016年9月14日 · Gene target information for HLA-DRA - major histocompatibility complex, class II, DR alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

HLA class II histocompatibility antigen, DR alpha chain is a protein in humans that is encoded by HLA-DRA gene. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells.