HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. [5] DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of rheumatoid arthritis. [6] [7]

2024年12月25日 · HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) is a Protein Coding gene. Diseases associated with HLA-DRB1 include Multiple Sclerosis and Sarcoidosis 1. Among its related pathways are TCR Signaling (Qiagen) and Phosphorylation of …

The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and ...

HLA-DRB1 属于 HLA II 类β链旁系同源物。 II 类分子是由 alpha (DRA) 和 beta 链 (DRB) 组成的异二聚体，两者都锚定在膜中。它通过呈递源自细胞外蛋白的肽在免疫系统中发挥核心作用。 II 类分子在抗原呈递细胞中表达。 β 链约为 26-28 kDa。它由 6 个外显子编码。

G表示具有相同的第2、3外显子序列的一组HLA-I类等位基因或具有相同第2外显子序列的一组II类等位基因：如DRB1*12:01:01G包括了DRB1*12:01、DRB1*12:10。 HLA与免疫治疗. 与肿瘤免疫检查点抑制剂相关的HLA类型主要是HLA-I类基因，CD8+ T细胞只有识别HLA I类分子呈递出来的短肽，才能够被激活。 HLA I类分子主要包括HLA-A，HLA-B，HLA-C三类。

Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning both as a component of the patient’s genome and as an environmental risk factor.

Gene ID: 3123, updated on 8-Feb-2025. HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

HLA-DRB1 is one of several genes in the HLA complex that have been associated with rheumatoid arthritis; variations of this gene are the most significant known genetic risk factor for the disease.

2017年10月9日 · HLA-DRB1 is one the HLA genes that make up the human major histocompatibility complex, surface antigens that regulate the immune system, contributing the beta-1 subunit of the HLA-DR receptor, along with B3-B5. It …

hla-drb1属于hla ii类β链平行基因。ii类分子是一个由α（dra）和β链（drb）组成的核心异二聚体，两者都固定在膜上。它通过呈现来自细胞外蛋白的肽来在免疫系统中发挥核心作用。ii类分子在抗原呈递细胞中表达。β链约为26-28 kda。它由6个外显子编码。