2024年12月18日 · 谷丙转氨酶alt是临床上应用最广泛的肝功能检查指标，它用于判断肝脏是否受损。 ALT主要存在于肝细胞当中，肝细胞中的ALT浓度比血液高1000-3000倍。 只要有少量的肝细胞受损，ALT就会明显升高，因此，ALT可以用作肝细胞变性和坏死的判断指标，也可以用于评估 ...

2020年12月18日 · 反映肝实质损害的指标，主要包括谷丙转氨酶（Alanine Transaminase, ALT）和谷草转氨酶 (Aspartate Aminotransferase, AST)。 ALT 是最常用的敏感指标，1% 的肝细胞发生坏死时，血清 ALT 水平可升高 1 倍，ALT 水平与肝脏损伤程度呈正比。

2025年1月29日 · What Is an ALT Blood Test? The alanine aminotransferase (ALT) test is a blood test that checks for liver damage. ALT used to be called serum glutamic-pyruvic transaminase (SGPT). Your doctor...

2019年11月13日 · In this study, we investigated the role of HLF in HSC during aging and leukemogenesis. We first confirmed that HLF is expressed all through ontogeny by performing quantitative PCR on HSC and progenitor populations from mouse fetal liver (E14.5 FL) and bone marrow (BM) of aged mice (18-month-old mice).

An alanine transaminase (ALT) blood test measures the amount of ALT in your blood. ALT levels in your blood can increase when your liver is damaged, so healthcare providers often use an ALT blood test to help assess the health of your liver.

Komorowska et al. report that the transcription factor HLF is required to maintain hematopoietic stem cell (HSC) function during regeneration. Moreover, Hlf-deficient HSCs are less quiescent. In accordance with this, toxic insults targeting dividing cells completely eradicate the HSC pool in Hlf-deficient mice.

2013年11月15日 · Moreover, HLF has been described as a regulator of circadian rhythm and recent findings have implicated HLF as a candidate “stemness” gene in both normal and malignant stem cells. Accordingly, overexpression of HLF in human hematopoietic stem cells (HSC) results in an enhanced reconstitution capability in NOD-SCID mice.

2024年4月26日 · A high ALT level is usually a sign of some type of liver issue. It’s important to work with your doctor to find the underlying cause of your elevated ALT, even if you don’t have any symptoms.

2013年11月15日 · Moreover, HLF has been described as a regulator of circadian rhythm and recent findings have implicated HLF as a candidate “stemness” gene in both normal and malignant stem cells. Accordingly, overexpression of HLF in human hematopoietic stem cells (HSC) results in an enhanced reconstitution capability in NOD-SCID mice.

2024年2月27日 · This review focuses on the significance of ALT in assessing hepatic injury and malfunction. ALT is aggregated primarily in the cytosol of hepatocytes, consists of 496 amino acids, and has a half-life of approximately 47 hours. ALT is detectable in serum at low concentrations (typically <30 IU/L).