The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. HMG family proteins include HMGB, HMGN, and HMGA subfamilies, which are highly evolutionarily conserved nuclear proteins.

High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. [1] HMG proteins were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels. [2]

High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA …

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses on the similarities and differences in the mecha …

HMGB1（High mobility group box-1 protein，高迁移率族蛋白B1） 是存在于真核细胞核内的非组蛋白染色体结合蛋白，参与DNA损伤修复和基因组稳定性维持。 HMGB1属于 HMG蛋白家族，因其在 聚丙烯酞胺凝胶电泳 (PAGE)中迁移速度快且没有聚集迹象而得名。 HMG家族包含HMGB、HMGN和HMGA三个高度保守的核蛋白亚家族。 与其他同家族蛋白相比，HMGB1存在范围更广，在哺乳动物的几乎所有细胞和组织内均有表达。 HMGB1是一个高度保守的含有215个氨基 …

2010年1月1日 · HMG boxes bind to the minor groove of B-form DNA, significantly widen the groove and introducing a bend of 90° or more into the backbone. HMGB proteins also bind with high affinity to already distorted DNA structures such as four-way junctions, bulges, kinks and modified DNA containing cisplatin adducts [122] .

1999年6月1日 · Here, we demonstrate that the first step in enhanceosome assembly, i.e. HMG I(Y)‐dependent recruitment of NF‐κB and ATF‐2/c‐Jun to the enhancer, is facilitated by discrete regions of HMG I and is mediated by allosteric changes induced in the DNA by HMG I(Y) and not by protein–protein interactions between HMG I(Y) and these proteins.

1973年，高迁移率族蛋白B1（HMGB1）首次在小牛胸腺中被发现并鉴定出来，其作为染色质的结构蛋白，有助于将DNA包装到染色体中。 目前，根据其特征功能序列基序将HMG蛋白分为三个亚家族——HMGA（HMG-14和HMG-17）、HMGB（HMG-1和HMG-2）和HMGN（HMG-I和HMG-Y）。 许多HMG蛋白现在已知在不同的位置具有不同的功能。 其中研究最广泛的是HMGB1，其参与了许多重要的生理和病理过程。 这些功能包括促进细胞核中的DNA损伤修复、感应核酸和 …

洛伐他汀的研发目标是抑制胆固醇合成过程中的限速酶 羟甲戊二酰辅酶A还原酶 （HMG-CoA还原酶），从而降低血胆固醇和低密度脂蛋白胆固醇水平，预防动脉粥样硬化和冠心病等心血管疾病。 他汀类药物经历了三代技术更迭，目前主要由第三代的 阿托伐他汀 、 瑞舒伐他汀 和 匹伐他汀 占据市场主导地位。 这些药物具有更优异的临床效果和安全性，是降血脂治疗的首选药物。 洛伐他汀行业面临着激烈的竞争和政策监管的挑战，同时也有着广阔的发展机遇和潜力。 洛伐他汀 …

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