羟甲基戊二酸单酰辅酶A（英語： 3-hydroxy-3-methylglutaryl-CoA ，简称“HMG-CoA”）也称为“β-羟基-β-甲戊二酸单酰辅酶A”或“3-羟基-3-甲戊二酸单酰辅酶A”，是一种重要的脂类 代谢中间产物。

β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl coenzyme A, is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase .

hmg-coa还原酶： 肝细胞 合成 胆固醇 过程中的 限速酶 ，催化生成 甲羟戊酸 ，抑制hmg-coa还原酶能阻碍胆固醇合成。

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that …

2023年7月3日 · HMG-CoA reductase inhibitors (statins) are lipid-lowering medications used in the primary and secondary prevention of coronary heart disease. This activity reviews the indications, contraindications, and mechanism of action of statins for the management of coronary heart disease and familial dyslipidemias.

羥甲基戊二酸單醯輔酶A還原酶（英語： hydroxymethylglutaryl-CoA reductase ，EC 1.1.1.88 （頁面存檔備份，存於網際網路檔案館））簡稱「HMG-CoA還原酶」，是一種以NAD + 或NADP + 為受體、作用於供體 CH-OH 基團上的氧化還原酶。

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids.

β-hydroxy-β-methylglutaryl-CoA;HMG-CoA 定 义 物质代谢中重要的中间产物。由3分子乙酰辅酶A缩合而成。裂解时可生成酮体；还原时可生成甲羟戊酸，是动植物中萜类、固醇类化合物的前体。

3-Hydroxy-3-Methylglutaryl-Coenzyme A is an intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from acetyl coenzyme A and acetoacetyl CoA by HMG-CoA (3-Hydroxy-3 …

2024年7月5日 · hmg-coa合酶是一种酶，全称为3-羟基-3-甲基戊二酰辅酶a合酶，这种酶在肝脏的表达最多，而肝脏又是脂肪酸代谢最核心的器脏，因此酮体在肝脏产出最多。