HMGA2 contains three basic DNA-binding domains (AT-hooks) that cause the protein to bind to adenine - thymine (AT)-rich regions of nuclear DNA. HMGA2 does not directly promote or inhibit the transcription of any genes, but alters the structure of DNA and promotes the assembly of protein complexes that do regulate the transcription of genes.

2024年12月25日 · HMGA2 (High Mobility Group AT-Hook 2) is a Protein Coding gene. Diseases associated with HMGA2 include Silver-Russell Syndrome 5 and Salivary Gland Adenoma, Pleomorphic. Among its related pathways are Cellular responses to stimuli and Overlap between signal transduction pathways contributing to LMNA laminopathies.

有研究已证实高迁移率族蛋白A2（HMGA2）基因是一种新的癌基因，且其表达的HMGA2蛋白促进肿瘤增殖、侵袭，有望成为一种新的基因治疗靶点，然而关于其致癌的发病机制以及HMGA2与肿瘤治疗的关系尚不清楚，文章就HMGA2与肿瘤之间关系研究进展进行综述。 HMGA蛋白于1983年首次从人子宫颈癌细胞中分离提纯，其相对分子质量约为10×10 3[1]，最初命名HMGI-C，21世纪初改为HMGA2。 高迁移率组蛋白家族分为HMGA、HMGB和HMGN三大类，其中HMGA又可 …

2023年10月12日 · Here we show that HMGA2 mediates direct condensation of polynucleosomes and forms droplets with nucleosomes. Consistently, most endogenous HMGA2 localized to transposase 5– and DNase...

HMGA2 increases cancer cell proliferation by promoting cell cycle entry and inhibition of apoptosis. In addition, HMGA2 influences different DNA repair mechanisms and promotes epithelial-to-mesenchymal transition by activating signaling via the MAPK/ERK, TGFβ/Smad, PI3K/AKT/mTOR, NFkB, and STAT3 pathways.

HMGA2 is an important biomarker to predicting nasopharyngeal carcinoma patient's survival time. HMGA2 is predominantly amplified and expressed in AML cells, and that aberrant expression of HMGA2 induces AML cell proliferation through the PI3K/Akt/mTOR signaling pathway.

HMGA (high mobility group A) (HMGA1 and HMGA2) are small non-histone proteins that can bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors to the DNA and contributing to the overall panorama of gene expression tuning.

2024年3月16日 · HMGA2 binds and promotes cis-element modification in the promoter region of the GPX4 gene by enhancing enhancer activity through increased H3K4 methylation and H3K27 acetylation. Furthermore,...

HMG 蛋白作为结构因子发挥作用，是增强体的重要组成部分。 该蛋白质包含结构 DNA 结合域，可作为转录调节因子。 鉴定与粘液样脂肪肉瘤相关的该基因的缺失、扩增和重排表明其在脂肪形成和间充质分化中起作用。 小鼠对应物的基因敲除研究表明，该基因与饮食引起的肥胖有关。 已经表征了编码不同亚型的替代转录剪接变体。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family.

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow.