2021年1月18日 · In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in cancer (e.g., the Wnt/β-catenin,...

2017年6月5日 · HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in populations with high genetic diversity.

2019年7月16日 · Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation ...

2019年6月1日 · Genes related to ferroptosis are controlled by transcription factors HIC1 and HNF4A. Stimulation of ferroptosis breaks the balance between HIC1 and HNF4A. Lower HIC1 with higher HNF4A has poorer clinical outcomes in liver cancer patients. Ferroptosis is an outcome of metabolic disorders and closely linked to liver cancer.

2024年7月6日 · We aimed to evaluate the utility of immunohistochemistry (IHC) expression subtypes generated by unsupervised hierarchical clustering based on staining scores of four markers (CK5/6, p63, GATA6,...

Hepatocyte nuclear factor 4-alpha (HNF4α) is a transcription factor with important roles in liver and gastrointestinal tract development, hepatocyte differentiation, and lipid and glucose metabolism [1].

肝细胞核因子4A(hepatocyte nu- clear factor 4A，HNF4A)是一种含有锌指结构的配 体依赖性转录因子，属于核受体超家族成员之一，由 11 个内含子和12 个外显子组成[2]。 HNF4A 不仅 是葡萄糖、脂肪酸和脂质代谢过程中的核心成员和 中枢调节剂，而且具有调节桥粒、粘着连接和紧密连 接3 个主要区室内多种成分表达的能力[3]。 因此， HNF4A 的异常表达和癌症的发生发展密切相关。 研究[4 －6]表明HNF4A 在食管癌、肝癌和结肠癌中作 为促癌基因或抑癌基因参与疾病进展， …

Additional evaluation of HNF4A protein status using IHC in a third independent in-house cohort of treatment-naïve EAC tumor biopsy tissues (n=44) showed markedly distinct HNF4A protein expression, as well as HNF4A targets (VIL1, EPS8L3), in EAC tumors (Figure 1I). Taken together the RNAseq and protein analyses, we estimate the majority of ...

2011年12月9日 · Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24 and miR-629.

2022年1月28日 · To explore weather HNF4A inhibits tumor formation and tumor growth of cervical cancer cells by inhibiting cell proliferation, the expression of Ki67, which is an important cell proliferation marker, was evaluated in xenografts by IHC (Figures 3(a) and 3(b)).