2021年1月18日 · In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in …

2017年6月5日 · HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in …

2019年7月16日 · Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by …

2019年6月1日 · Genes related to ferroptosis are controlled by transcription factors HIC1 and HNF4A. Stimulation of ferroptosis breaks the balance between HIC1 and HNF4A. Lower HIC1 …

2024年7月6日 · We aimed to evaluate the utility of immunohistochemistry (IHC) expression subtypes generated by unsupervised hierarchical clustering based on staining scores of four …

Hepatocyte nuclear factor 4-alpha (HNF4α) is a transcription factor with important roles in liver and gastrointestinal tract development, hepatocyte differentiation, and lipid and glucose …

肝细胞核因子4A(hepatocyte nu- clear factor 4A，HNF4A)是一种含有锌指结构的配 体依赖性转录因子，属于核受体超家族成员之一，由 11 个内含子和12 个外显子组成[2]。 HNF4A 不仅 是 …

Additional evaluation of HNF4A protein status using IHC in a third independent in-house cohort of treatment-naïve EAC tumor biopsy tissues (n=44) showed markedly distinct HNF4A protein …

2011年12月9日 · Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular …

2022年1月28日 · To explore weather HNF4A inhibits tumor formation and tumor growth of cervical cancer cells by inhibiting cell proliferation, the expression of Ki67, which is an important cell …