
Hepatocyte nuclear factor 4α and cancer-related cell ... - Nature
2021年1月18日 · In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in …
HNF4A expression as a potential diagnostic tool to discriminate …
2017年6月5日 · HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in …
Defective HNF4alpha-dependent gene expression as a driver of ... - Nature
2019年7月16日 · Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by …
Ferroptosis is governed by differential regulation of transcription …
2019年6月1日 · Genes related to ferroptosis are controlled by transcription factors HIC1 and HNF4A. Stimulation of ferroptosis breaks the balance between HIC1 and HNF4A. Lower HIC1 …
Combination immunohistochemistry for CK5/6, p63, GATA6, and HNF4a …
2024年7月6日 · We aimed to evaluate the utility of immunohistochemistry (IHC) expression subtypes generated by unsupervised hierarchical clustering based on staining scores of four …
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and …
Hepatocyte nuclear factor 4-alpha (HNF4α) is a transcription factor with important roles in liver and gastrointestinal tract development, hepatocyte differentiation, and lipid and glucose …
肝细胞核因子4A(hepatocyte nu- clear factor 4A,HNF4A)是一种含有锌指结构的配 体依赖性转录因子,属于核受体超家族成员之一,由 11 个内含子和12 个外显子组成[2]。 HNF4A 不仅 是 …
HNF4A Defines Molecular Subtypes and Vulnerability to TGFβ …
Additional evaluation of HNF4A protein status using IHC in a third independent in-house cohort of treatment-naïve EAC tumor biopsy tissues (n=44) showed markedly distinct HNF4A protein …
An HNF4α-miRNA Inflammatory Feedback Circuit regulates …
2011年12月9日 · Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular …
HNF4A Regulates the Proliferation and Tumor Formation of …
2022年1月28日 · To explore weather HNF4A inhibits tumor formation and tumor growth of cervical cancer cells by inhibiting cell proliferation, the expression of Ki67, which is an important cell …