DNA and nitrous acid - ScienceDirect
1975年12月4日 · Methyl methanesulfonate produces many depurinations and practically no cross-linked DNA molecules, whereas it is the opposite with HNO 2. It is concluded that the loss of …
【生物化学】亚硝酸引起的DNA诱变机制 - 百度贴吧
亚硝酸（HNO2）及其盐中N原子具有中间氧化态+3，虽然它们既具有氧化性，又具有还原性，但以氧化性为主。 它可以引起氧化脱氨作用，使胞嘧啶（C）转化成尿嘧啶（U），发生碱基转 …
Mechanisms of DNA damage, repair and mutagenesis - PMC
At least five major DNA repair pathways—base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR) and non-homologous end …
Nitrous acid (HNO2) as a mutagen. The nitrous acid alter an …
Figure 1 shown how expose of DNA to nitrous acid can convert the base adenine (A) to a form that no longer pair with thymine (T) but instead pairs with cytosine (C). When DNA containing …
Effects of nitrous acid treatment on the survival and mutagenesis …
2023年12月1日 · Deoxyinosine occurs in DNA by spontaneous deamination of adenine or by incorporation of dITP during replication. Hypoxanthine residues (HX) are mutagenic and give …
Nitrous Acid | HNO2 | CID 24529 - PubChem
2009年6月17日 · Nitrous acid is a mutagenic agent. It can induce interstrand cross-links in duplex DNA, preferentially at d(CpG) steps: two guanines on opposite strands are linked via a single …
亚硝基胍（NTG）诱变 - 知乎 - 知乎专栏
2024年4月11日 · 在碱性条件下，NTG会形成 重氮甲烷 (CH2N2)，它是引起致死和突变的主要原因。 它的效应很可能是CH2N2对DNA的 烷化作用 引起的。 NTG诱变根据《遗传学综合实验》 …
What are Chemical Mutagens? Definition and Types - Biology …
A common deaminating agent, i.e. nitrous acid (HNO2), replaces an -NH2 or amino group with an –OH or ether group, thereby altering the DNA bare pairing. In simple words, deaminating …
化学诱变剂 - 百度百科
hno2还能造成dna双链间的交联而引起遗传效应。 叠氮化钠(NaN3) 是一种呼吸抑制剂，能引起 基因突变 ，可获得较高的突变频率，而且无残毒。 新手上路
Structure and function of cross-linked DNA: II. Loss of reversibility ...
DNA containing interstrand cross-links resulting from reaction with nitrous acid has been used in an attempt to gain insight into the process of transformation of Bacillus subtilis. DNA reisolated …