Role of HOXA9 in leukemia: dysregulation, cofactors and essential ...
2015年6月1日 · HOXA9 is a homeodomain-containing transcription factor that has an important role in hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A …
HOXA9 Gene - GeneCards | HXA9 Protein | HXA9 Antibody
2024年12月25日 · HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include Leukemia, Acute Lymphoblastic and Hematologic Cancer. Gene Ontology …
Molecular regulators of HOXA9 in acute myeloid leukemia
Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in patients. …
HOXA9 - Wikipedia
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. [5] [6] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are …
HOXA9 transcription factor is a double-edged sword: from …
The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness, epithelial-mesenchymal transition (EMT), metastasis, and generation of the tumor microenvironment in …
HOXA9 homeobox A9 [Homo sapiens (human)] - Gene - NCBI
2025年2月8日 · Title: Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis. RNA-binding protein RBM5 plays an …
Direct and Indirect Targeting of HOXA9 Transcription Factor in …
HOXA9 (Homeobox A9) is a homeotic transcription factor known for more than two decades to be associated with leukemia. The expression of HOXA9 homeoprotein is associated with …
HOXA9 has the hallmarks of a biological switch with ... - Nature
2022年10月3日 · HOXA9 plays an important role in acute myeloid leukaemia (AML) prognosis by promoting blood cell expansion and altering differentiation; however, the function of HOXA9 in …
RNA-binding protein RBM5 plays an essential role in acute …
2024年1月2日 · Ectopic expression of HOXA9 rescues impaired leukemia cell proliferation upon RBM5 loss. Importantly, acute protein degradation of RBM5 through auxin-inducible degron …
Role of HOXA9 in solid tumors: mechanistic insights and …
2022年11月14日 · This review details the signaling pathways, binding partners, post-transcriptional regulation of HOXA9, and possible inhibitors of HOXA9 in solid tumors, which …