2024年12月25日 · HOXD13 (Homeobox D13) is a Protein Coding gene. Diseases associated with HOXD13 include Synpolydactyly 1 and Syndactyly, Type V. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is HOXA13.

HOXD13 is the first of several HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities.

2025年2月8日 · Title: HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2.

哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，分别位于不同的染色体上，由 9～11 个串联排列的基因组成。 该基因是位于 2 号染色体簇中的几个同源框 HOXD 基因之一。 删除整个 HOXD 基因簇或该簇 5' 端的缺失与严重的肢体和生殖器异常有关。 这个特定基因的突变会导致多指畸形。 [RefSeq 提供，2008 年 7 月] This gene belongs to …

2025年1月4日 · Clinical resource with information about HOXD13, Brachydactyly type D, Brachydactyly type E1, Brachydactyly-syndactyly syndrome, Syndactyly type 5, Synpolydactyly type 1, and available tests.

HOXD13 suppresses prostate cancer metastasis and BMP4-induced epithelial-mesenchymal transition by inhibiting SMAD1. Genome sequencing in families with congenital limb malformations. GALNT10 promotes the proliferation and metastatic ability of gastric cancer and reduces 5-fluorouracil sensitivity by activating HOXD13.

We revealed the function and mechanism of HOXD13 in colon cancer and suggest that HOXD13 may be a candidate marker for the diagnosis and treatment of colon cancer.

通过对多个SPD家系进行遗传学研究，目前已发现其致病基因为同源盒D13 (homeobox D13，HOXD13)。 HOXD13基因位于HOXD基因簇的5’端，在脊椎动物肢体发育中起着至关重要的作用。

HOX基因家族在脊椎动物的肢体发育中发挥巨大的作用.隶属于HOXD基因群的HOXD13基因参与肢体最远端 (手和脚)的发育过程.HOXD13基因突变可以导致并多指 (趾)畸形.随着研究的深入,新的突变以及疾病类型不断被发现,对HOXD13基因的结构与功能,以及HOXD13基因突变引起的 ...

2021年6月15日 · Our findings establish HOXD13 as a negative regulator of prostate cancer progression and metastasis by preventing BMP4/SMAD1 signaling, and potentially suggest new strategies for targeting metastatic prostate cancer.