HP1α is a chromatin crosslinker that controls nuclear and …
2021年6月9日 · Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromatin protein HP1α (CBX5) is unknown. We used a novel …
HP1a: A Structural Chromosomal Protein Regulating Transcription
Heterochromatin Protein 1 (HP1a in Drosophila) is a conserved eukaryotic chromosomal protein that is prominently associated with pericentric heterochromatin and mediates the concomitant …
Functions of HP1 proteins in transcriptional regulation - PMC
Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene regulation through a variety of molecular …
HP1α is a chromatin crosslinker that controls nuclear and mitotic ...
Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromatin protein HP1α (CBX5) is unknown. We used a novel HP1α …
Phase separation drives heterochromatin domain formation
2017年6月21日 · We show that Drosophila HP1a protein undergoes liquid–liquid demixing in vitro, and nucleates into foci that display liquid properties during the first stages of heterochromatin …
Heterochromatin protein 1 (HP1a in Drosophila) is a conserved eukaryotic chromosomal protein that is pro-minently associated with pericentric heterochromatin and mediates the concomitant …
Insights into HP1a-Chromatin Interactions - PMC
2020年8月9日 · Over the years, several works have taken on the task of identifying HP1a partners using different strategies. In this review, we focus on describing these interactions and the …
Heterochromatic 3D genome organization is directed by HP1a
2024年5月24日 · Here, we examine the roles of HP1a and methylated histone H3 lysine 9 (H3K9), two hallmarks of constitutive heterochromatin, in determining 3D genome organization during …
Functions of HP1 proteins in transcriptional regulation
2022年5月7日 · Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene regulation through a variety …
Liquid droplet formation by HP1α suggests a role for phase
2017年6月21日 · We show by direct protein delivery into mammalian cells that an HP1α mutant incapable of phase separation in vitro forms smaller and fewer nuclear puncta than …