
DNA损伤修复机制——非同源末端链接NHEJ和同源重组HR
2020年4月3日 · Nuclease-induced double strand breaks (DSBs) can be repaired by nonhomologous end joining (NHEJ) or homology-directed repair (HDR) pathways. Imprecise …
Homologous recombination in DNA repair and DNA damage …
2008年1月1日 · Homologous recombination (HR) is a DNA metabolic process found in all forms of life that provides high-fidelity, template-dependent repair or tolerance of complex DNA …
DNA损伤反应与DNA的修复(二) - 知乎专栏
nhej和hr是dsb修复的两种主要方式,细胞需要选择针对特定情况的最佳修复途径。 NHEJ在G1/S/G2期都可以起作用,而HR仅在DNA复制后的S期和G2期才有活性。 在S和G2期的DSB …
Homologous recombination in DNA repair and DNA damage …
Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In addition, …
Recruitment and rejoining of remote double-strand DNA breaks …
2025年3月11日 · To distinguish between repair outcomes, we performed genomic amplification using primer F (upstream of the VEGFA DSB) and primer I. This allowed us to identify and …
DNA 损伤修复通路 | Cell Signaling Technology
同源重组(HR)也是 DSB 的模板指导修复。 当 ssDNA 的末端被包括 MRN 复合体在内的核酸内切酶降解时,这是一个高度调控的通路。 接下来,末端用 RPA 细丝覆盖,并用 RAD51 取 …
Repair of Strand Breaks by Homologous Recombination - PMC
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and …
Nature子刊:中山大学松阳洲团队发现DNA损伤修复通路的新选 …
DNA双链断裂(DNA double-strand break,DSB)是一种常见且高度有害的DNA损伤形式,严重威胁着基因组稳定性和细胞存活。DSB修复缺陷或失调与肿瘤、衰老以及免疫缺陷等密切相关。
Nature | 邹力团队揭示基因转录促进同源重组修复的分子机制 - 知乎
DNA双链断裂修复主要通过 非同源末端连接 (Non-homologous End Joining, NHEJ)和 同源重组 (Homologous Recombination, HR)来完成,其中NHEJ容易出错并引入突变而HR具有高度的 …
End resection: a key step in homologous recombination and
2020年11月27日 · DNA end resection in eukaryotes is a key step in DNA homologous recombination (HR) and HR-mediated DNA double-strand break (DSB) repair, in which DNA2, …