HR is a gene encoding Protein hairless. [5] [6] [7] This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. [7]

2024年12月25日 · HR (HR Lysine Demethylase And Nuclear Receptor Corepressor) is a Protein Coding gene. Diseases associated with HR include Alopecia Universalis Congenita and Atrichia With Papular Lesions. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity.

2011年7月6日 · HR was the first gene identified to be implicated in hair-cycle regulation. Point mutations in HR lead to congenital human hair loss, which results in the complete loss of body and scalp...

2025年2月8日 · Findings indicate that hairless (HR) is a H3K9 demethylase that regulates epidermal homeostasis via direct control of its target genes. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.

The HR gene encodes a nuclear receptor corepressor that is critical for the maintenance of hair growth (Potter et al., 2001). Ahmad et al. (1998) delineated the entire coding sequence of the human 'hairless' gene, which consists of 1189 amino acids.

HR was the first gene identified to be implicated in hair-cycle regulation. Point mutations in HR lead to congenital human hair loss, which results in the complete loss of body and scalp...

2023年11月23日 · This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases.

2025年2月8日 · Hr evokes an anti-apoptotic response by disrupting a p53 dependent pathway involving Bcl2 family members. Hr mutants display partial hair loss at an early age and progress to near alopecia. Mutation of the Hr gene results in congenital hair loss in both mice and men

HR was the first gene identified to be implicated in hair-cycle regulation. Point mutations in HR lead to congenital human hair loss, which results in the complete loss of body and scalp hairs. HR functions are indispensable for initiation of postnatal hair follicular cycling.

We demonstrate that the development of the hr/hr phenotype is an exquisitely regulated process, whose precise temporal and cell-type-specific sequence of events strongly suggests critical roles for the hr gene product in normal HF regression, namely in the control of intrafollicular apoptosis and tissue integrity during catagen.