2018年9月10日 · We propose HRD1 as a liver metabolic regulator and a potential drug target for obesity, fatty liver disease, and insulin resistance associated with the metabolic syndrome.

Hrd1和Der1都具有一个可以调控底物进入的侧门并在膜内彼此面对；同时，Hrd1和Der1 各有一个亲水性凹槽，分别位于细胞质一侧和内质网腔一侧。 这两种蛋白质都会扭曲位于侧门附近的脂质膜结构，使其比正常的 磷脂双层 更薄，这一发现进一步得到了 分子动力学 ...

2024年2月16日 · Proteomic screens of SEL1L and HRD1 interactomes reveal that SEL1L-HRD1 interaction is a prerequisite for the formation of a functional HRD1 ERAD complex, as SEL1L is required for the...

2023年5月4日 · Here we report that the SEL1L–HRD1 protein complex—the most conserved branch of ER-associated degradation (ERAD)—is a negative regulator of the STING innate immunity by ubiquitinating and...

2004年1月30日 · We show that human HRD1 is a non-glycosylated, stable ER protein with a cytosolic RING-H2 finger domain. In the presence of the ubiquitin-conjugating enzyme UBC7, the RING-H2 finger has in vitro ubiquitination activity for Lys (48)-specific polyubiquitin linkage, suggesting that human HRD1 is an E3 ubiquitin ligase involved in protein degradation.

2004年1月30日 · In this study we characterized the structure and function of the putative human orthologue of yeast Hrd1p/Der3p, designated human HRD1. We show that human HRD1 is a non-glycosylated, stable ER protein with a cytosolic RING-H2 finger domain.

HRD1 forms a ubiquitin ligase complex with SEL1L which stabilizes HRD1 proteins and facilitates substrate recognition by the complex 38, 51 (Figure S4A). Consistently, silencing SEL1L using siRNA oligos increased the amount of the heat shock-induced SGs while inhibiting disassembly (Figures 3A, 3B, and S4B).

2025年2月24日 · grina通过促进hrd1介导的atf6泛素化减轻肝脏缺血再灌注损伤引发的细胞凋亡和内质网自噬; 上海营养与健康研究所李于团队首次揭示了肝细胞中通过蛋白磷酸酶ppp6c调节mash发育的新信号轴！

2021年12月16日 · To our knowledge, HRD1 is the first E3 ubiquitin ligase identified that regulates the m 6 A modification process through targeting METTL14 for degradation. Therefore, HRD1 is a dominant-negative regulator of m 6 A mRNA modification and thus plays a role in cellular adaptation to ER stress via the ERm 6 A mechanism.

2017年10月1日 · The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD, but their roles and how they assemble with Hrd1 are not well understood.