2020年5月15日 · Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages of blood and immune cells. The maintenance of blood homeostasis requires a dynamic response...

Acute myeloid leukemia (AML) is characterized by disruption of HSC and progenitor cell differentiation. Frequently, AML is associated with mutations in genes encoding epigenetic modifiers. We hypothesized that analysis of alterations in DNA methylation patterns during healthy HSC commitment and diff …

2024年11月5日 · 该研究发现，在HSC起源的白血病转化过程中，这些表观遗传程序被部分保留，与癌基因（MLL::AF9易位）驱动的程序协同作用，这种结合效应导致HSC起源的AML的侵袭性增加。 该研究同时发现，AML细胞的起源对MLL::AF9易位的作用也有显著影响。 虽然MLL::AF9能够在不同的造血细胞类型中驱动白血病发生，但它对HSC-AML的影响较弱，部分关键的白血病干细胞程序（如MEIS1、PBX3、MEF2C等）似乎并不完全依赖MLL::AF9，而是在HSC中通过 …

2025年1月27日 · HDAC1 is a key oncogene in AML, linked to prognosis. c-JUN activity is elevated in AML progenitor cells and is associated with HDAC1 expression. Inhibiting c-JUN enhances resistance to acute myeloid leukemia cells. The combined targeting of c-JUN and HDAC1 demonstrates potent anti-tumor efficacy in a …

2021年11月1日 · HSC quiescence is carefully controlled by both intrinsic and extrinsic, niche-driven mechanisms. In acute myeloid leukemia (AML), the leukemic cells overtake the hematopoietic bone marrow niche where they acquire a quiescent state. These dormant AML cells are resistant to chemotherapeutics.

2016年7月1日 · Hematopoietic stem cells (HSCs) are localized to hypoxic niches in bone marrow. Hypoxia-inducible factors play key roles in the maintenance of HSCs. HSCs display peculiar metabolic features, which are modulated by hypoxia and differentiation. Leukemia cells reprogram their metabolism to sustain survival and proliferation.

2013年11月11日 · LSC and normal hematopoietic stem cells (HSC) share many characteristics and co-exist in the bone marrow of AML patients. For the development of successful LSC-targeted therapy, enabling eradication of LSC while sparing HSC, the identification of differences between LSC and HSC residing within the AML bone marrow is crucial.

2021年3月1日 · Here, we demonstrate that LSCs, HSCs, and pre-leukemic stem cells can be identified and molecularly profiled by combining single-cell transcriptomics with lineage tracing using both nuclear and...

2025年1月27日 · We identified the activity of c-JUN is specifically enhanced in HSC-Prog in AML patients. We suggest a potential regulatory relationship between c-JUN and HDAC1 in AML tumor cells. Inhibition of c-JUN can suppress cell proliferation and CD33 expression in AML, enhancing susceptibility to natural killer (NK) cell-mediated cytotoxicity.

2016年1月7日 · Here, we address 3 important issues in the field of postremission therapy by alloHSCT or autoHSCT in first complete response (CR1) in patients with AML: What is the current place of reduced-intensity conditioning (RIC) and nonmyeloablative (NMA) alloHSCT in both older and younger patients with AML in CR1?