This niche is generally separated into 2 sections: Endosteal niche-the outer edge of the bone marrow that contains osteocytes, bone matrix, and quiescent HSCs. Perivascular niche-the …

2024年9月10日 · HSCs are unique amongst stem and progenitor cell pools in that they engage with multiple physically distinct niches during their ontogeny. HSCs are specified from …

2019年2月11日 · The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation,...

Schofield在1978年提出骨髓造血干细胞（HSC）生态位（niche）的概念[1]，生态位由血管、神经和多种细胞组成，主要是间充质干细胞（MSC）和内皮细胞（EC），这些细胞构成维持干细 …

2017年6月12日 · Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and …

干细胞微环境(Stem cell niche，直译：干细胞龛)是干细胞的集中存储部位，通过特定的细胞外基质和微环境细胞提供特殊的微环境，对维持干细胞的高增殖力和诱导定向分化起关键作用。

2024年4月23日 · Our findings fill a critical knowledge gap by unambiguously discovering a pathway that specifically regulates the generation of the HSC niche and demonstrating that …

Here, we review the recent advances on the niches for HSCs and their immunological progeny, built on a historical perspective of the cellular and molecular constituents, focusing on murine …

2017年1月1日 · The biochemical cues generated by the niche regulate vital cellular functions such as the proliferation, differentiation, homing, engraftment, and maintenance of tissue …

The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and proliferation. …