Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated …
2019年11月21日 · Through transcriptional control of the evolutionarily conserved heat shock, or proteotoxic stress, response, heat shock factor 1 (HSF1) preserves proteomic stability. Here, …
Nat Chem Biol | 项晟祺/侯中怀/姚雪彪揭示HSF1温度依赖性相分离机制|细胞|翻译|活性|hsf…
2025年1月11日 · 热休克转录因子1（HSF1） 是这一反应的核心调控因子，能够快速感知温度变化并诱导分子伴侣等基因的表达，从而维持细胞内蛋白质稳态。HSF1的活性受到翻译后修饰 …
Suppression of the HSF 1‐mediated proteotoxic stress response by the ...
2014年11月25日 · Identification of AMPK ‐mediated HSF 1 suppression by metabolic stress not only showcases a complex, interwoven network of cellular stress responses, but also pinpoints …
Regulation of heat shock transcription factors and their roles in ...
2017年8月30日 · Heat shock transcription factors (HSFs) have broad roles in stress resistance that encompass protection from protein misfolding, inflammation and environmental...
AMPK‐mediated formation of stress granules is required for …
We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR …
HSF1 as a Cancer Biomarker and Therapeutic Target - PMC
HSF1 is negatively regulated by AMPK and PGC-1α [27, 87, 88]. AMPK acts as a tumor suppressor and is a cellular metabolic stress sensor and maintains cellular energy …
孙育杰课题组揭示HSF1的可诱导和可逆相分离介导热休克转录应答 …
2022年3月18日 · 作者综合使用超分辨显微成像、体外重构和多组学等技术，建立了一个精细调节HSF1相分离的模型来探索热休克条件下转录激活的分子机制。 热休克会诱导细胞核内应激颗 …
AMPK-mediated formation of stress granules is required for …
We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR …
Regulation of aging and age-related disease by DAF-16 and heat …
2003年5月16日 · The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging …
(PDF) Suppression of the HSF1-mediated proteotoxic
2014年11月1日 · Surprisingly, we discovered that metabolic stress suppresses the PSR. This suppression is largely mediated through the central metabolic sensor AMPK, which physically …