2023年6月27日 · Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts as a prime modifier of the c-MYC-mediated transcription. HSF1 deficiency diminishes c-MYC DNA binding and dampens its transcriptional activity genome wide.

The HSF1 protein regulates the heat shock response (HSR) pathway in humans by acting as the major transcription factor for heat shock proteins. The HSR plays a protective role by ensuring proper folding and distribution of proteins within cells.

2022年7月29日 · We examined effects of reduced histone acetylation on the interaction between the TRIM proteins and HSF1, and found that TRRAP KD or TIP60 KD reduced co-precipitation of the H3K18ac reader...

2024年12月25日 · Complete information for HSF1 gene (Protein Coding), Heat Shock Transcription Factor 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

基于热休克期间hsf1的翻译后修饰（ptm）调控其转录活性的报道，作者通过构建一系列突变体和体外磷酸化hsf1，阐明了特定位点的ptm驱动hsf1相分离。 为了进一步探究HSF1相分离对转录调控的影响，作者使用双色超分辨成像发现HSF1招募转录机器共相分离，形成转录 ...

2020年2月3日 · Here we report that condensation and phase transition of heat-shock factor 1 (HSF1), a transcriptional regulator of chaperones 1, 2, is integral to cell-fate decisions underlying survival or...

2010年11月9日 · In a proteomic study of HSF1 binding partners, we have discovered its association with the pleiotropic protein kinase A (PKA). HSF1 binds avidly to the catalytic subunit of PKA, (PKAcα) and becomes phosphorylated on a novel serine phosphorylation site within its central regulatory domain (serine 320 or S320), both in vitro and in vivo.

2022年3月9日 · 该机制揭示了HSF1活性的动态调节过程，即在急性应激期间有效驱动HSPs基因转录并在热休克停止后适时终止转录，维持细胞内蛋白质稳态。 基于HSF1的动态调控谱绘了细胞内的“冰与火之歌”。 致谢. 感谢孙育杰研究员对本文的支持。 参考文献.

2021年5月31日 · We herein demonstrated that HSF1 interacted with MED12 and recruited MED12 and CDK8 to the HSP70 promoter during heat shock in mammalian cells. The kinase activity of CDK8 (and its paralog CDK19) promoted HSP70 expression partly by phosphorylating HSF1-S326 and maintained proteostasis capacity.

2023年6月27日 · To determine the necessity of HSF1, we examined the expression of c-MYC target genes in immortalized mouse embryonic fibroblasts (MEFs) following transient Hsf1 knockdown (KD). Hsf1 KD diminished the transcripts of these target genes (Figure S1 B).