Over the past decade, our laboratory has developed a secreted heat shock protein (HSP), chaperone gp96, cell-based vaccine that generates effective anti-tumor and anti-infectious immunity in vivo. Gp96-peptide complexes were identified as an extremely efficient stimulator of MHC I-mediated antigen c …

2024年2月21日 · 该团队利用gp96细胞特异性敲除的小鼠模型，发现gp96蛋白对于 自然杀伤细胞 （NK细胞）对肿瘤的杀伤功能、产生 IFN-γ 能力、对 IL-15 的反应性至关重要，敲除gp96后成熟的NK细胞比例下降了约25倍，对肿瘤抑制活性显著降低，并对IL-15的反应大幅降低， 说明gp96驱动 ...

HSP gp96 also known as glucose-regulated protein grp94, is the primary chaperone of the endoplasmatic reticulum. Gp96/grp94, because of its peptide chaperone capacity and its ability to interact actively with professional antigen-presenting cells (APCs), is also endowed with crucial immunological functions such as natural adjuvant for priming ...

2021年11月17日 · Immunization of gp96 increased Treg frequency, expansion, and suppressive function. Gene expression profiling identified the NF-κB family member p65 and c-Rel as the key transcription factors for enhanced Foxp3 expression in Treg by gp96.

Heat shock proteins like gp96 (grp94) are able to induce specific cytotoxic T-cell (CTL) responses against cells from which they originate and are currently studied in clinical trials for use in immunotherapy of tumors.

2016年7月19日 · In this study, the prototypical immunogenic HSP, gp96, is used to investigate the role of NK cells in rejection of tumors in murine models of cancer.

2013年11月20日 · Over the past decade, our laboratory has developed a secreted heat shock protein (HSP), chaperone gp96, cell-based vaccine that generates effective anti-tumor and anti-infectious immunity in vivo.

2024年10月28日 · 同时HSP70、gp96及HSP60本身具有活化巨噬细胞、树突状细胞 (抗原递呈细胞)的作用，从而增强了共刺激因子和MHC的表达；它还活化自然杀伤细胞 (NK细 胞)及受体为y/δ的T细胞，即非MHC限制的免疫活化。

2017年5月31日 · Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas high-dose immunization primes responses characterized by regulatory T (Treg) cells and...

2021年1月22日 · Glucose-regulated protein 94 (GRP94, also known as Gp96) is an endoplasmic reticulum (ER) member of the heat shock protein HSP90 family whose expression is...