HSP60 is one of the most conserved proteins expressed in all species, and is also named as chaperonin or Cpn60. Two groups of chaperonins are found to be expressed in different locations in cells.

2024年12月25日 · Complete information for HSPD1 gene (Protein Coding), Heat Shock Protein Family D (Hsp60) Member 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

HSP60 is a chaperone that belongs to class I chaperones (Caruso Bavisotto et al., 2020). HSP60 binds unfolded proteins and catalyzes their folding in an ATP-dependent manner (Bigman and Horovitz, 2019).

2021年9月8日 · HSP60 plays a myriad number of roles like chaperoning, thermotolerance, apoptosis, cancer, immunology and embryonic development. In this review we discussed briefly the general knowledge and focussed on HSP60 in terms of structure, regulation and function in various physiological and pathological conditions.

2017年12月5日 · The mammalian molecular chaperone, HSP60, plays an essential role in protein homeostasis through mediating protein folding and assembly.

Hsp60 is a chaperone belonging to the Chaperonins of Group I and typically functions inside mitochondria in which, together with the co-chaperonin Hsp10, maintains protein homeostasis.

2024年5月17日 · The HSP60 family, encompassing Cpn60, plays diverse roles in cellular processes, including protein folding, cell signaling, and managing high-temperature stress. In prokaryotes, HSP60 is well understood as a GroEL/GroES complex, which forms a double-ring cavity and aids in protein folding.

Heat shock proteins 60 (HSP60) is one of the most well studied member of the HSP family. Although found to be a target self antigen in pathological autoimmunity and HSP60-reactive T and B cells are part of immune responses in several infectious ...

2023年8月5日 · Starting from its biological function, this review aims to provide a comprehensive understanding of the potential involvement of Hsp60 in Alzheimer's disease (AD) and Type II Diabetes Mellitus (T2DM), which are known to share …

In this article, we comprehensively review the regulative mechanisms of HSP60 on apoptosis, its applications as a cancer diagnostic biomarker and a therapeutic target, evidence of involvement in tumour resistance and the applications of exosomal HSP60 in liquid biopsy.