2024年12月25日 · HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) is a Protein Coding gene. Diseases associated with HSPA5 include Mucormycosis and Japanese Encephalitis. Among its related pathways are Unfolded Protein Response (UPR) and Response to elevated platelet cytosolic Ca2+.

Binding immunoglobulin protein (BiPS) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. [5][6]

HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma. HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer. Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis.

HSPA5（Heat Shock Protein 70 kDa 5，又称BiP，Binding Immunoglobulin Protein）是一种热休克蛋白，在细胞内起着多种重要的生物学功能。 它在细胞应激响应、蛋白质折叠、质量控制以及细胞凋亡等生物过程中发挥着…

2017年4月15日 · Here, we show that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, activating transcription factor 4 (ATF4) resulted in the induction of HSPA5, which in turn bound glutathione peroxidase 4 (GPX4) and protected against GPX4 protein degradation and ...

2023年5月8日 · Heat shock protein family A (Hsp70) member 5 (HSPA5) is an endoplasmic reticulum chaperone, which regulates cell metabolism, particularly lipid metabolism. While HSPA5’s role in regulating cell...

于是作者通过测量 Xbp1s （由IRE1介导的剪接Xbp1转录本）和Hspa5（ATF6目标基因）的总体种群水平表达来监测IRE1和ATF6的活性。研究人员验证了Xbp1s和Hspa5在Tm处理开始后的12和15小时最大程度地诱导，并在24小时后显着降低。

Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A member 5). [provided by Alliance of Genome Resources, Apr 2022]

hspa5，即热休克蛋白家族a成员5”，别名bip、grp78。它是一种分子伴侣蛋白，主要在内质网中发挥作用，由人体细胞自身的基因编码。hspa5的作用机制涉及帮助蛋白质的正确折叠、组装和运输。

2023年5月18日 · HSPA5, highly expressed in the malignant tumors, likely plays a critical role in SARS-CoV-2 invasion/attack in cancer patients via tumor tissues. In the current study, we review the newest research progresses on cell surface protein HSPA5 expressions, functions, and mechanisms for cancers and SARS-CoV-2 invasion.