The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR.

The HSQC (Heteronuclear Single Quantum Coherence) experiment is used to determine proton-carbon single bond correlations, where the protons lie along the observed F2 (X) axis and the carbons are along the F1 (Y) axis. An edited HSQC spectrum of …

2023年2月11日 · In an HSQC spectrum, a 13 C or heteroatom spectrum is displayed on one axis and a 1 H spectrum is displayed on the other axis. Cross-peaks show which proton is attached to which carbon or heteroatom. The purpose of a HSQC is to determine which protons are coupled to what other specific carbon or heteroatom in the molecule through bonds.

HSQC谱可联系相隔1个共价键的氢核和碳核，如-CH-。 如下图，当知道某氢核的谱峰位置，顺藤摸瓜，通过QC谱图，找到相对应的碳核信号。 如遇像-CH2-这两个氢非化学等价的情况，那么一个碳信号就会对应两个氢信号，此时，且位于两个氢信号的中间位置。 一维氢谱和碳谱描述了单个原子信息，2D NMR中的1H-1H COSY和HSQC，组合了相近原子间的信息，通过以上方式，我们仅知道分子的片段信息，只有再把片段与片段信息组合起来，我们才可知道整个分子的信息。 …

Every expno must be contained within a dataset name. Thus, for the dataset called “RSS_01234”, for example, there could be a 1H experiment in expno 1, an HSQC in expno 2, and an HMBC in expno 3. Within RSS_01234/3/pdata/1 would be the processed HMBC, and RSS_01234/3/pdata/99 might contain a projection from the 2D HMBC dataset.

2024年6月14日 · HSQC is a sophisticated two-dimensional NMR technique that plays a crucial role in the study of molecular structures. It is termed 'heteronuclear' because it involves interactions between two different types of nuclei, typically 1H,13C or 15N.

By default, SI2=SI1=1K and pure cosine squared sine window functions (WDW2=WDW1=QSINE) are applied to both dimensions (SSB2=SSB1=2) using MC2 (TPPI, States-TPPI ...) as defined in FnMODE. Linear prediction can optionally be applied in the indirect F1 dimension. Use the TOPSPIN plot editor (xwinplot)

多糖的结构解析中，hsqc二维核磁是开展糖苷键连接确认的基础谱图。 从有机物的HSQC解谱而言，代表的相连接的C-H相关，比如乙醇CH3-CH2-OH，其HSQC谱图中，甲基的质子和甲基碳有相交叉的信号，而亚甲基质子和亚甲基…

HSQC - Heteronuclear Multiple Quantum Correlation. This 2D experiment correlates the chemical shift of proton with the chemical shift of the directly bonded carbon. On the bottom axis is a proton spectrum and on the other is a carbon. Cross peaks give …

How to acquire and process multiplicity-edited HSQC spectra: phasing 2D data, loading high-resolution projections, setting contrast colors in Level Tool, plotting, HMQC versus HSQC, data interpretation.