The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR. The experiment was first described by Geoffrey Bodenhausen and D. J. Ruben in 1980. [1]

HSQC谱可联系相隔1个共价键的氢核和碳核，如-CH-。 如下图，当知道某氢核的谱峰位置，顺藤摸瓜，通过QC谱图，找到相对应的碳核信号。 如遇像-CH2-这两个氢非化学等价的情况，那么一个碳信号就会对应两个氢信号，此时，且位于两个氢信号的中间位置。 一维氢谱和碳谱描述了单个原子信息，2D NMR中的1H-1H COSY和HSQC，组合了相近原子间的信息，通过以上方式，我们仅知道分子的片段信息，只有再把片段与片段信息组合起来，我们才可知道整个分子的信息。 …

在核磁共振（NMR）技术中，HSQC（Heteronuclear Single Quantum Coherence，异核单量子相关谱）和HMBC（Heteronuclear Multiple Bond Correlation，异核多键相关谱）是两种常用的二维谱图方法，它们主要用于确定有机分子中碳原子和氢原子之间的关联，从而帮助解析分子结构。

异核单量子关系（HSQC）, 隶属于NMR（核磁共振）C-H COSY 谱图 中的一种，此外还有多键 碳氢 关系谱 HMBC 及异核多量子关系 HMQC。 HSQC给出的信息是直接相连的 碳氢 关系，给出一键CH连接问题，而不能解决碳与季碳相连的问题，或隔碳相连的问题。 HMQC 和HSQC,这两种图谱的作用与H-CCOSY相当，由于是反向实验，灵敏度高。 二者相比HSQC优点更多一些。 当 样品量 较多时，宜做H-CCOSY。 异核单量子关系（HSQC）, 隶属于NMR（核磁共振）C-H …

Sigma-Aldrich. 855642. N-Acetyl-L-glutamic acid. Quick View. Sigma-Aldrich. G1251. L-Glutamic acid. Quick View. Sigma-Aldrich. A0783. N-Acetyl-L-proline. Quick View. Sigma-Aldrich. M0876. ... Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water ...

2012年1月1日 · The relative merits of the HSQC sequence and the alternative HMQC sequence are discussed, and the performances of different versions of the HSQC sequence are evaluated, using three test compounds. It is shown that recent modifications of the HSQC sequence have eliminated or minimized earlier weaknesses of this sequence, leading to a more than ...

Constant time INEPT CT-HSQC (CTi-CT-HSQC) - A new NMR method to measure accurate one-bond J and RDCs with strong 1H-1H couplings in natural abundance. Strong (1)H- (1)H coupling can significantly reduce the accuracy of (1)J (CH) measured from frequency differences in coupled HSQC spectra.

2011年11月8日 · HSQC-1,1-ADEQUATE covariance spectra derived by co-processing of GHSQC and 1,1-ADEQUATE spectra allow the carbon skeleton of molecules to be conveniently traced. HSQC-1,n-ADEQUATE spectra provide enhanced access to correlations equivalent to 4J (CH) correlations in a GHMBC spectrum.

2006年11月3日 · A new analytical method based on the 2D HSQC NMR sequence is presented, which can be applied for quantitative structural determination of complicated polymers. The influence of T1 and T2 relaxations, off-resonance effects, coupling constants and homonuclear couplings are discussed.

2023年12月25日 · 多糖的结构解析中，hsqc二维核磁是开展糖苷键连接确认的基础谱图。从有机物的hsqc解谱而言，代表的相连接的c-h相关，比如乙醇ch3-ch2-oh，其hsqc谱图中，甲基的质子和甲基碳有相交叉的信号，而亚甲基质子和亚甲基…