The HSQC (Heteronuclear Single Quantum Coherence) experiment is used to determine proton-carbon single bond correlations, where the protons lie along the observed F2 (X) axis and the carbons are along the F1 (Y) axis. An edited HSQC spectrum of …

The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR.

2023年2月11日 · Hetereonuclear Single Quantum Coherence (HSQC) is used to determine the proton to carbon or heteroatom (often nitrogen) single bond correlations. It is also known as heteronuclear multiple quantum coherence (HMQC).

HSQC - Heteronuclear Multiple Quantum Correlation. This 2D experiment correlates the chemical shift of proton with the chemical shift of the directly bonded carbon. On the bottom axis is a proton spectrum and on the other is a carbon. Cross peaks give …

Gained Information: The Heteronuclear Single Quantum Correlation (HSQC) NMR experiment is a proton-detected 2D experiment that shows you 1H / 13C one-bond connectivity. You will see your 1H spectrum as your direct F2 axis and your 13C spectrum as your indirect F1 axis.

Heteronuclear Single Quantum Coherence (HSQC) is a technique used in NMR spectroscopy to simultaneously record 1H and 13C chemical shifts by coupling 1H nuclei with other NMR-active nuclei directly bonded to them, providing structural information in complex mixtures.

Subse-quently, heteronuclear single quantum coherence (HSQC) sequence was developed (12). The distinc-tion between these two proton-detected heteronuclear correlation techniques (10–14) is that IS-spin coher-ence is stored as multiquantum (HMQC) or single-quantum (HSQC), during the t1 evolution period.

2012年1月1日 · As the title suggests, this chapter focuses on HSQC and HMBC spectra, two critically important spectra for organic structure determination by two-dimensional NMR. The relative merits of the HSQC sequence and the alternative HMQC sequence are discussed, and the performances of different versions of the HSQC sequence are evaluated, using three ...

2003年3月14日 · A quantitative method to record 1 H-13 C correlation NMR spectra (Q-HSQC) is presented. The suppression of 1 J CH-dependence is achieved by modulating the polarization transfer delays of HSQC. In addition, the effect of homonuclear couplings, as well as relaxation during the pulse sequence are discussed.

Make some assignments of your compound based on COSY, TOCSY and HSQC data. Look in particular for entry points in the spectra, some proton and/or carbon that can be assigned with definiteness that show correlations in the COSY/TOCSY spectra.