2022年1月14日 · Certain infected patients develop neurological autoimmune disorder called HTLV-1-associated myelopathy, also known as tropical spastic paraparesis (HAM/TSP). Both viruses are transmitted between individuals via blood transfusion, tissue/organ transplantation, breastfeeding, and sexual intercourse.

Retroviral coinfections with HIV-1 and HTLV-1 or with HIV-1 and HTLV-2 occur with variable frequencies throughout the world with the highest prevalence in large metropolitan areas in the Americas, Europe, and Africa. The recognition that retroviral coinfections exist dates back to the discovery of HIV-1 over 25 years ago.

HIV/HTLV-1 coinfection is associated with accelerated progression to AIDS and worse outcomes of HIV-related opportunistic infections. 5 - 7 Human T-cell lymphotropic virus type 1 induces HIV viral replication and the transition from M- to T-tropic HIV phenotype, which is often a marker of HIV disease progression. 8 In addition, compared to ...

HTLV-1 is a highly cell associated virus which mainly integrates influencing through its regulatory protein the function of host cells. Differently from HIV-1, HTLV-1 virus spread relies mainly on vertical transmission (mitotic spread), while a role can be also played by horizontal transmission (infectious spread).

2024年11月11日 · Multiple studies have revealed co-infected patients with HTLV-2 and HIV-1. In this paper, we formulated a new mathematical model for the co-infection of HTLV-2 and HIV-1 in vivo. The HIV-1-specific B-cell response is included.

2024年9月27日 · In this review, we present recent findings on the assembly mechanisms of Human T-cell leukemia virus type 1 and highlight key differences from HIV-1, focusing particularly on the molecular determinants of Gag–PM interactions and CA assembly.

在这篇综述中，我们讨论了每种传播方式对 HIV-1 和 HTLV-1 生物学的机制和重要性。 到目前为止，只有两种逆转录病毒，即人类免疫缺陷病毒 (HIV)（1 型和 2 型）和人类 T 细胞嗜淋巴细胞病毒 1 型 (HTLV-1)，已被认为对人类具有致病性。 两种病毒主要感染 CD4+ T 淋巴细胞。 HIV 复制诱导 CD4 淋巴细胞凋亡，导致获得性免疫缺陷综合征 (AIDS) 的发展。 经过长时间的临床潜伏期后，HTLV-1 可以转化淋巴细胞，随后出现不受控制的增殖，并出现一种称为成人 T 细胞白血病 …

2018年5月8日 · It's related to HIV, yet you've probably never heard of it: a virus called human T-cell leukemia virus type 1, or HTLV-1. But now, high rates of HTLV-1 in parts of Australia are prompting...

2020年12月29日 · In the present paper, we formulate an HTLV/HIV dual infection model. The model includes the impact of the Cytotoxic T lymphocyte (CTLs) immune response, which is important to control the dual infection.

2024年5月25日 · In 2018, we asked WHO to adopt the sexually transmitted oncovirus, human T-cell leukaemia virus 1 (HTLV-1) as a threat to human health. 1 Consequently, WHO announced that HTLV-1's elimination is targeted in their Global Health Sector Strategies on HIV, viral hepatitis, and sexually transmitted infections by 2030. 2 WHO also assigned a new ...