2024年12月4日 · HTLV-1 is primarily transmitted through breast feeding, sexual contact, needle sharing and unsafe blood transfusion. Mother-to-infant transmission occurs primarily through breastfeeding at a rate of around 20–30%, with shorter durations of breastfeeding associated with lower rates of transmission.

A high maternal HTLV-1 PVL (defined as HTLV-1 DNA copies/100 peripheral blood mononuclear cells [PBMCs] expressed as a percentage of cells infected given there is a single copy per cell) has been found to be an independent risk factor for increased transmission to the infant .

Vertical transmission of HTLV-1/2 could theoretically occur during the intrauterine period or during delivery, but it is has been shown that it is through breastfeeding that the majority of its transmission occurs, with HTLV-infected cells entering the infant's body by the oral route.

In this review, we critically analyze HTLV-1 pathogenesis, epidemiology, diagnosis, associated diseases, preventive strategies, and treatments, with emphasis to the emerging risk for Europe and particularly Spain, focusing on prevention methods …

What are the anatomical sites and cellular targets of initial HTLV-1 infection in the infant? Why do higher titres of anti-HTLV-1 antibodies in the mother increase the risk of mother-to-child transmission (MTCT) with HTLV-1?

2023年9月18日 · HTLV-1 is transmitted through unprotected sexual intercourse, contact with infected blood (blood transfusion, organ transplantation or contact with sharp objects) and mother-to-child transmission, mainly through breastfeeding.

2022年11月10日 · Human T lymphotropic virus 1 (HTLV-1) may be transmitted from mother to child and affects at least 5−10 million individuals worldwide, with severe consequences on health. Strategies to prevent transmission are important, as there is no treatment or vaccine. This systematic review aimed to identify i …

2024年5月5日 · Human T-cell lymphotropic virus type 1 (HTLV-1) is a neglected virus that can cause severe disease and be transmitted from mother to child through breastfeeding. Avoidance of breastfeeding prevents 80% of vertical transmission. The United Kingdom (UK) is currently assessing whether HTLV-1-targeted antenatal screening should be implemented.

2018年10月7日 · Breastfeeding has been reported to be the predominant route of vertical transmission of HTLV-I. The objective of this systematic review was to pool and evaluate the data on the transmission of HTLV-I with different infant-feeding practices on children born to HTLV-I-positive mothers.

2023年4月9日 · HTLV-1 is known to cause adult T-cell leukemia (ATL), an aggressive cancer of peripheral CD4 T cells; however, it is also responsible for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Most patients develop ATL as …