2016年4月18日 · 在HTLV-1的基因组上，除了编码逆转录病毒所必须的结构和功能蛋白以外，还编码着一系列的调节蛋白，包括Tax、Rex、HBZ等。 其中，最重要并且是研究最为广泛的，就是Tax。

The HTLV-1 Tax oncoprotein interacts with a plethora of host cellular proteins to regulate viral gene expression and also promote the aberrant activation of signaling pathways such as NF-κB to drive clonal proliferation and survival of T cells bearing the HTLV-1 provirus.

2020年7月7日 · The HTLV-1 Tax oncoprotein interacts with a plethora of host cellular proteins to regulate viral gene expression and also promote the aberrant activation of signaling pathways such as NF-κB to drive clonal proliferation and survival of T cells bearing the HTLV-1 provirus.

2005年9月5日 · Our current understanding is that Tax is the primary HTLV-1-encoded factor used by the virus to modulate cellular proliferation. During virus replication, the Tax protein is a transcriptional...

2025年3月16日 · The length of the HTLV-1 provirus is only approximately 9 kb in size.The HTLV-1 provirus encodes several regulatory (tax and rex) and accessory genes (p12, p13, p30, and HTLV-1 bZIP factor [HBZ]) (Fig. 1).Among these viral genes, tax and HBZ have been shown to be important for de novo and persistent HTLV-1 infection.Tax is encoded in the sense strand and activates viral transcription.

2010年11月5日 · The HTLV-1 proto-oncogene Tax, a potent transcriptional activator of cellular and viral genes, is thought to play a pivotal role in the transforming properties of the virus by deregulating intracellular signaling pathways.

2021年9月20日 · Tax and HBZ are two viral regulatory proteins encoded by the human T-cell leukemia virus type 1 (HTLV-1) via sense and antisense transcripts, respectively. Both proteins are known to drive oncogenic processes that culminate in a T-cell neoplasm, known as Adult T cell leukemia/lymphoma (ATLL).

2008年8月14日 · Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins.

2017年12月21日 · Two HTLV-1 genes, tax and HTLV-1 basic leucine zipper factor (HBZ), have been demonstrated to play important roles in HTLV-1 infectivity and the growth and survival of leukemic cells. Increased HTLV-1 Tax expression induces the expression of various cellular genes such as IL-2 and IL-15, which directly contributes to lymphocyte activation and ...

1 天前 · The amount of HTLV-1 proviral DNA was determined using the following formula: copy number of HTLV-1 tax per 1 × 10 4 PBMCs = [(copy number of Tax)/(copy number of β − actin/2)] × 10 4. All samples were examined in triplicate. Real …