
HTR2A Gene - GeneCards | 5HT2A Protein | 5HT2A Antibody
2024年12月25日 · HTR2A (5-Hydroxytryptamine Receptor 2A) is a Protein Coding gene. Diseases associated with HTR2A include Obsessive-Compulsive Disorder and Major Depressive Disorder. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).
5-HT2A receptor - Wikipedia
The 5-HT 2A receptors is coded by the HTR2A gene. In humans the gene is located on chromosome 13. The gene has previously been called just HTR2 until the description of two related genes HTR2B and HTR2C. Several interesting polymorphisms have been identified for HTR2A: A-1438G , C102T , and His452Tyr . Many more polymorphisms exist for the gene.
Get to know a gene: HTR2A - GeneSight
2017年7月14日 · What is HTR2A? The 5-HT2A receptor, encoded by the HTR2A gene, is responsible for post-synaptic serotonin signaling and is a target for many antipsychotics and antidepressants. 1 Two single nucleotide polymorphisms (SNPs) in HTR2A, rs6311 (-1438G>A) and rs6313 (102C>T), have been studied for associations with response and side effects ...
【探索】5-HT2A受体激活相关的潜在影响及最新研究进展 - 知乎
5-HT2A靶点全称:5-hydroxytryptamine receptor 2A 又名HTR2A , 5-HT2A, HTR2, 5-羟色胺受体2A,5-HT2A 受体是广泛分布于全身的 G 蛋白偶联受体,据研究发现抑郁症患者比正常人拥有更多的 5-HT2A受体 ,这也表明该类疾病发病机制与5-HT2A受体数量增多有直接的关联,
药化综述|神经治疗靶点|5-羟色胺2A受体 - 知乎
5-HT2A受体是血清素系统中的关键组分,与多种生物学功能和神经精神障碍相关。 5-HT2A受体激动剂,包括经典精神活性药物如LSD和 psilocybin,通过与受体的正交结合位点结合,产生精神活性效果。 5-HT2A受体的分子结构和功能研究揭示了其在 G蛋白偶联受体 中的保守性和特异性。 非精神活性5-HT2A受体激动剂的开发为治疗神经精神障碍提供了新的策略,这些化合物可能通过促进神经可塑性来发挥治疗作用。 5-HT2A受体异构调节剂作为一类新型药物,通过与受体的非正 …
HTR2A 5-hydroxytryptamine receptor 2A [ (human)] - National …
HTR2A selectively activates radial glia cells in the developing human, but not mouse, neocortex, and inhibiting HTR2A receptors in human radial glia disrupts the radial glial scaffold. The results show that overweight in boys with ADHD is associated with polymorphisms in 5HTR2A, but not through conditioning deficits in cognitive functions.
5-羟色胺 (血清素) 受体 2A(Htr2a)基因 | MCE
该基因的人类直系同源基因与多种疾病有关,包括酒精使用障碍;神经性厌食症;严重抑郁症;肥胖;和强迫症。 与人 HTR2A(5-羟色胺受体 2A)同源。 [由基因组资源联盟提供,2022 年 4 月] Predicted to enable several functions, including 1- (4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity.
5-羟色胺受体 2A(HTR2A)基因 | MCE - MCE-生物活性分子大师
该基因的突变与精神分裂症和强迫症的易感性有关,也与重度抑郁症 (MDD) 患者对抗抑郁药西酞普兰的反应有关。 在该基因的内含子 2 中也有突变的 MDD 患者显示出对西酞普兰的反应显着降低,因为这种抗抑郁药会下调该基因的表达。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供,2009 年 9 月] This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles.
Genomic structure and expression of the human serotonin 2A …
RNA sequencing redefined the architecture of the serotonin 2A receptor gene (HTR2A), revealing novel mRNA transcript isoforms utilizing unannotated untranslated regions of the gene. Expression of these untranslated regions is modulated by common single nucleotide polymorphisms (SNPs), namely rs6311.
Cell:首次解析出致幻剂与5-HT2A血清素受体结合在一起时的三维 …
他们首次解析出这些致幻剂与脑细胞表面上的5-HT2A血清素受体(5-HT2A serotonin receptor, HTR2A)结合在一起时的高分辨率结构。 相关研究结果发表在2020年9月17日的Cell期刊上,论文标题为“Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor”。